Table 3 Risk factors for flare during the course of pregnancy

 TNFi before pregnancy^a and discontinued at positive pregnancy test

10 of 22 (45.5)

5 of 53 (9.4)

3.333

(1.8–6.1)

0.001*

10 of 15 (66.7)

14 of 46 (30.4)

3.083

(1.2–7.9)

0.017*

 TNFi during first trimester

3 of 22 (13.6)

5 of 53 (9.4)

1.322

(0.5–3.5)

0.686

6 of 15 (40)

12 of 46 (26.1)

1.593

(0.7–3.8)

0.340

 GCs before pregnancy

8 of 22 (36.4)

17 of 53 (32.1)

1.143

(0.6–2.4)

0.790

1 of 15 (6.7)

4 of 46 (8.7)

0.800

(0.1–4.9)

0.642

 GCs during first trimester

8 of 22 (36.4)

17 of 53 (32.1)

1.143

(0.6–2.4)

0.790

1 of 15 (6.7)

6 of 46 (13)

0.551

(0.1–3.6)

0.178

 DMARDs before pregnancy

10 of 22 (45.5)

22 of 53 (41.5)

1.120

(0.6–2.3)

0.801

3 of 15 (20)

5 of 46 (10.9)

1.656

(0.6–4.6)

0.589

 DMARDs during first trimester

8 of 22 (36.4)

22 of 53 (42.5)

0.860

(0.4–1.8)

0.798

2 of 15 (13.3)

3 of 46 (6.5)

1.723

(0.5–5.6)

0.589

 NSAIDs before pregnancy

2 of 22 (9.1)

6 of 53 (11.3)

0.838

(0.2–2.9)

0.568

3 of 15 (20)

15 of 46 (32.6)

0.597

(0.2–1.9)

0.518

 NSAIDs during first trimester

3 of 22 (13.6)

6 of 53 (11.3)

1.158

(0.4–3.1)

0.716

3 of 15 (20)

15 of 46 (32.6)

0.597

(0.2–1.9)

0.518

 Active disease before pregnancy^a

5 of 22 (22.7)

9 of 53 (17.0)

1.282

(0.6–2.9)

0.536

2 of 15 (13.3)

4 of 46 (8.7)

1.410

(0.4–4.8)

0.630

 Active disease during first trimester

8 of 22 (36.4)

10 of 53 (18.9)

0.456

(0.2–0.9)

0.038*

5 of 15 (33.3)

11 of 46 (23.9)

0.717

(0.3–1.7)

0.510

 Elevated CRP before pregnancy^a

3 of 22 (13.6)

8 of 53 (15.1)

0.584

(0.3–1.3)

0.282

1 of 15 (6.7)

2 of 46 (4.3)

0.724

(0.1–3.8)

0.718

 Elevated CRP during first trimester

9 of 22 (40.9)

12 of 53 (22.6)

0.553

(0.2–0.7)

0.008*

7 of 15 (46.7)

6 of 46 (13)

0.280

(0.1–0.7)

0.006*