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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

Fig. 3

The associations between smoking and DNA methylation (cg21325723) in all individuals (a), and in individuals with rs6933349_GG, rs6933349_AG, or rs6933349_AA genotypes, respectively (b), in the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study. Each dot represents an individual and red horizontal bars mark average DNA methylation levels. The statistical significance (P value) of association between DNA methylation and smoking status, measured by Student’s t test, is indicated at the bottom of the plot

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