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Table 3 Baseline phosphorylatad Janus kinase fluorescence intensities in peripheral blood leukocytes of patients and healthy reference subjects

From: Baseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1-year treatment response in early rheumatoid arthritis

Fluorescence Cell type Patients (n = 35) Healthy control subjects (n = 17) p Value
pJAK1-PE CD4+ T 385 (92) 335 (75) 0.054
  CD8+ T 387 (89) 365 (79) 0.41
  CD19+ B 549 (151) 497 (121) 0.23
  CD14+ Mo 863 (240) 737 (193) 0.06
pJAK2-PE CD4+ T 4443 (1446) 3885 (1484) 0.20
  CD8+ T 4282 (1792) 4016 (1761) 0.62
  CD19+ B 7675 (3026) 6340 (2680) 0.12
  CD14+ Mo 6571 (2703) 4727 (1674) 0.011
pJAK3-PerCP CD4+ T 823 (197) 773 (163) 0.37
  CD8+ T 1350 (283) 1388 (396) 0.69
  CD19+ B 1040 (214) 994 (213) 0.47
  CD14+ Mo 2035 (442) 1976 (385) 0.65
pTyk2-PE CD4+ T 380 (144) 297 (41) 0.001
  CD8+ T 342 (128) 287 (43) 0.037
  CD19+ B 361 (177) 295 (51) 0.049
  CD14+ Mo 1118 (342) 827 (228) <0.001
  1. Abbreviations: pJAK Phosphorylated Janus kinase, Mo Monocyte, PE Phycoerythrin, PerCP Peridinin chlorophyll protein complex, Tyk Tyrosine kinase
  2. The fluorescence intensities are shown as means (SDs) in relative fluorescence units, with p values calculated using a permutation test