Fig. 2

Glucose, glutamine, and glutamate are more highly consumed in RA-FLS than in OA-FLS. a Relative levels of intracellular metabolites in 7 OA-FLS and 11 RA-FLS were analyzed by GC/MS. b Relative levels of intracellular metabolites in 3 OA-FLS and 3 RA-FLS were analyzed by CE-MS. Bars indicate mean ± SEM. *P < 0.05 by Mann-Whitney U test. CE-MS capillary electrophoresis-mass spectrometry, GC/MS gas chromatography-mass spectrometry, OA-FLS fibroblast-like synoviocytes from osteoarthritis patients, RA-FLS fibroblast-like synoviocytes from rheumatoid arthritis patients