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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

Fig. 6

GLS1 inhibition ameliorates autoimmune arthritis in SKG mice. Fourteen days after ZyA injection, compound 968 or DMSO was injected intraperitoneally into SKG mice three times per week (compound 968, n = 4; DMSO, n = 5). a Clinical arthritis scores were determined up to 42 days after ZyA injection. **P < 0.01 by two-way ANOVA using GraphPad Prism software. b Hind paws of compound 968- or DMSO-treated SKG mice were assessed for histopathological changes 42 days after ZyA injection. Arrows indicate the lining of the synovium. H&E original magnification × 40. c Histological arthritis scores were determined in the hind paws of compound 968- or DMSO-treated SKG mice. *P < 0.05 by Student’s t test. d Immunohistochemical analysis of Ki-67 expression in the right hind paws of compound 968- or DMSO-treated SKG mice on day 42; original magnification × 400. e Quantification of Ki-67 staining from (d). Bars indicate mean ± SEM. **P < 0.01 by Student’s t test. DMSO dimethyl sulfoxide, H&E hematoxylin and eosin, i.p. intraperitoneally

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