Fig. 6From: Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritisGLS1 inhibition ameliorates autoimmune arthritis in SKG mice. Fourteen days after ZyA injection, compound 968 or DMSO was injected intraperitoneally into SKG mice three times per week (compound 968, n = 4; DMSO, n = 5). a Clinical arthritis scores were determined up to 42 days after ZyA injection. **P < 0.01 by two-way ANOVA using GraphPad Prism software. b Hind paws of compound 968- or DMSO-treated SKG mice were assessed for histopathological changes 42 days after ZyA injection. Arrows indicate the lining of the synovium. H&E original magnification × 40. c Histological arthritis scores were determined in the hind paws of compound 968- or DMSO-treated SKG mice. *P < 0.05 by Student’s t test. d Immunohistochemical analysis of Ki-67 expression in the right hind paws of compound 968- or DMSO-treated SKG mice on day 42; original magnification × 400. e Quantification of Ki-67 staining from (d). Bars indicate mean ± SEM. **P < 0.01 by Student’s t test. DMSO dimethyl sulfoxide, H&E hematoxylin and eosin, i.p. intraperitoneallyBack to article page