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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling

Fig. 4

Emab selectively inhibits PRDM1 mRNA expression in CD10CD27 B cells. a Network of transcription factors involved in B-cell differentiation into Ab-producing cells. bd Tonsillar CD10CD27 B cells were negatively selected using magnetic bead cell separation and then stimulated with R848 (TLR7 agonist) and/or F(ab′)2 anti-human IgM with or without Emab or a human IgG control. RNA was isolated 12 hours after stimulation and expression of different genes was quantified by RT-PCR. *p < 0.05, **p < 0.01 as determined by two-way ANOVA with Bonferroni post test. Emab epratuzumab

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