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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis

Fig. 5

Pro-inflammatory role of extracellular S100A11. S100A11 significantly enhances the release of IL-6 (a) and TNF-α (b) in peripheral blood mononuclear cells and IL-6 (c) in synovial fibroblasts (SFs). Levels of TNF-α were not changed in SFs treated with S100A11 protein (d). Protein levels in cell culture supernatants were measured after 24 h. The horizontal line represents the median. Ctrl control, LPS lipopolysaccharide

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