Table 3 Improvement measures comparing base and BMD models in primary analysis
| Improvement measure | Outcome | Base model | BMD model | Comparison |
|---|---|---|---|---|
| Net reclassification improvement | Net % improvement | NRI (95% CI) | ||
| OA progression | Ref | 22% | 0.49 (0.20, 0.77) | |
| No OA progression | Ref | 27% | ||
| Integrated discrimination improvement | Base model average prediction | BMD model average prediction | IDI (95% CI) | |
| OA progression | 0.12 | 0.16 | 0.04 (0.01, 0.06) | |
| No OA progression | 0.09 | 0.09 |