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Table 4 Prediction of responder status at short term (2 weeks) and longer term (6 months) follow up, by baseline imaging characteristics

From: Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

Predictor variable in regression Short term responder at 2 weeks (yes/no) Longer term responder at 6 months (yes/no)
N Odds ratio (95% CI) P value N Odds ratio (95% CI) P value
MRI (WORMS)
 Synovitis maximal score (0–3) 109 0.82 (0.32 to 2.13) 0.689 109 0.43 (0.17 to 1.12) 0.084
 Bone marrow lesion maximal score (0–3) 109 0.76 (0.49 to 1.19) 0.231 109 1.12 (0.66 to 1.92) 0.668
 Bone attrition maximal score (0–3) 109 0.94 (0.56 to 1.57) 0.804 109 0.59 (0.32 to 1.10) 0.097
 Cartilage damage maximal score (0–6) 109 0.98 (0.75 to 1.27) 0.869 109 1.03 (0.74 to 1.42) 0.873
 Cyst maximal score (0–3) 108 0.74 (0.46 to 1.20) 0.222 108 1.27 (0.72 to 2.22) 0.408
 Menisci damage maximal score (0–6) 109 0.95 (0.74 to 1.20) 0.647 109 0.74 (0.55 to 0.98)* 0.039
 Osteophyte maximal score (0–7) 109 1.13 (0.86 to 1.49) 0.386 109 0.98 (0.70 to 1.38) 0.919
 Synovial effusion (0–3) 109 0.83 (0.52 to 1.31) 0.420 109 0.79 (0.44 to 1.41) 0.421
MRI (quantitative)
 Synovial tissue volume (per 1000 mm3) 111 1.00 (1.00 to 1.00) 0.612 111 0.96 (0.88 to 1.04) 0.327
Radiographs
 Tibiofemoral KL score (0–4) 187 0.79 (0.49 to 1.28) 0.341 187 0.52 (0.30 to 0.91)* 0.021
 Patellofemoral KL score (0–4) 188 0.86 (0.60 to 1.22) 0.391 188 0.80 (0.54 to 1.19) 0.269
 Overall KL maximal scorea (0–4) 188 0.72 (0.43 to 1.20) 0.205 188 0.43 (0.23 to 0.82)* 0.010
 Lateral tibiofemoral JSN score (0–3) 186 1.27 (0.79 to 2.03) 0.327 186 0.86 (0.51 to 1.45) 0.569
 Medial tibiofemoral JSN score (0–3) 187 0.91 (0.59 to 1.40) 0.661 187 0.69 (0.42 to 1.15) 0.154
 Patellofemoral JSN score (0–3) 179 0.83 (0.59 to 1.16) 0.265 179 0.85 (0.56 to 1.28) 0.425
 Overall JSN maximal scoreb (0–3) 187 0.75 (0.49 to 1.16) 0.196 187 0.60 (0.36 to 0.99)* 0.047
 Knee mal-alignment angle (per degree) 192 0.98 (0.92 to 1.04) 0.481 192 1.01 (0.94 to 1.08) 0.801
  1. MRI magnetic resonance imaging, WORMS Whole Organ Magnetic Resonance Imaging Score, KL Kellgren-Lawrence, JSN joint space narrowing. Results presented are from logistic regression. amaximal KL grade of the tibiofemoral or patellofemoral joint; bmaximal JSN score of the lateral or medial tibiofemoral or patellofemoral joint. *Represent results that are significant at p < 0.05