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Table 3 Clinical features by human leukocyte antigen B27 status

From: Multicenter inception cohort of enthesitis-related arthritis: variation in disease characteristics and treatment approaches

  Alla (n = 156) HLA-B27 positive (n = 69) HLA-B27 negative (n = 87) p Value
Demographics and clinical findings, n (%) or median (IQR)
 Age in years 11.5 (9.6, 13.6) 12.3 (10.3, 14.1) 11.0 (8.8,13.2) <0.01
 Sex, male 100 (64.1) 50 (72.5) 50 (57.5) 0.05
 Race, Caucasian 129 (82.7) 59 (85.5) 70 (80.5) 0.66
 Active joint count 2 (1–4) 3 (2–5) 2 (1–4) <0.01
 Tender entheses count 2 (2–4) 2 (1–3) 2 (2–5) 0.01
 MRI-defined sacroiliitis 22 (57.9) 15 (83.3) 7 (35.0) <0.01
 Polyarticular onset 36 (23.1) 20 (29.0) 16 (18.4) 0.15
 ANA-positive 31 (21.4) 10 (15.6) 21 (25.9) 0.13
 CRP, abnormal/elevated 31 (28.4) 13 (31.0) 18 (26.9) 0.65
 ESR, abnormal/elevated 57 (41.9) 34 (54.8) 23 (31.1) <0.01
Outcome measures, median (IQR)
 Physician disease activity (0–10) 2.4 (2–3) 2 (2–3) 2.6 (2–4) 0.07
 Juvenile Spondyloarthritis Disease Activity Index (JSpADA) (0–8) 3 (2.5–4) 3.5 (2.5–4) 3 (2.5–3.5) 0.04
 Patient/parent disease activity (0–10) 4 (2–6) 4 (2–5) 4 (2–6) 0.63
 Function (CHAQ) (0–3) 0.625 (0–1) 0.375 (0–1) 0.625 (0–1) 0.85
 Patient/parent pain (0–10) 4 (2–7) 4 (3–7) 4 (2–7) 0.71
 Juvenile Arthritis Disease Activity Score, excluding ESR (cJADAS) (0–30) 9 (5–13) 9 (5–13) 9 (5–14) 0.98
ILAR criteria, n (%)
 Acute, symptomatic uveitis 7 (4.5) 4 (5.8) 3 (3.5) 0.48
 Arthritis in a male over 6 years of age 93 (59.6) 50 (72.5) 43 (49.4) <0.01
 Family history of HLA-B27-associated disease 18 (11.5) 7 (10.1) 11 (12.6) 0.63
 Sacroiliac tenderness or lumbosacral pain 46 (29.5) 20 (29.0) 26 (29.9) 0.9
  1. Abbreviations: HLA-B27 Human leukocyte antigen B27, MRI Magnetic resonance imaging, ANA Antinuclear antibody, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, IQR Interquartile range, CHAQ Childhood Health Assessment Questionnaire
  2. Analyses restricted to patients who had both arthritis and enthesitis at the time of diagnosis. Denominators varied due to missing data: MRI-defined sacroiliitis (n = 38); ANA (n = 145); CRP (n = 109); ESR (n = 136); Physician disease activity (n = 97); JSpADA (n = 92); Patient/parent disease activity (n = 79); CHAQ (n = 92); Patient/parent pain (n = 100); cJADAS (JADAS3–10) (n = 69)
  3. a Six subjects who had arthritis and enthesitis at diagnosis were excluded because they were missing HLA-B27 status. P-values less than 0.05 are in italics and considered clinically significant