Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

Table 1 Summary of clinical, biochemical and cellular data on patients with RA and OA

^a PB peripheral blood, ^b SF synovial fluid, ^c SM synovial membrane, ^d RF rheumatoid factor, ^e ACPA anti-citrullinated protein antibody, ^f DAS28 disease activity score based on 28 joint counts, ^g ESR erythrocyte sedimentation rate, ^h CRP C-reactive protein (CRP), ⁱ NSAIDs non-steroidal anti-inflammatory drugs, ^j DMARDs disease-modifying anti-rheumatic drugs, ^k PBMCs peripheral blood mononuclear cells, ^l SFMCs synovial fluid mononuclear cells, ^m SMMCs synovial membrane mononuclear cells. *Mean, (values range). ^dRF nephelometry assay, cutoff value >15 UI/ml. All patients with RA had high positive ^dRF levels (more than three times the ULN for the laboratory and assay): 264 ± 190. ^eACPA: QUANTA Lite® CCP3.1 IgG/IgA ELISA (INOVA Diagnostics), cutoff value >20 UI/ml. All patients with RA had high positive ^eACPA levels (more than three times the ULN for the laboratory and assay):125 ± 64. ^hCRP cutoff value 1 mg/dl.

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