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Table 1 Summary of clinical, biochemical and cellular data on patients with RA and OA

From: Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

Characteristic Rheumatoid arthritis Osteoarthritis
PBa SFb SMc PBa SFb SMc
Number 25 9 4 11 10 9
RF (n)d 17 9 4    
ACPA (n)e 17 9 4 - - -
DAS28f index, low (0–3) mean 2.42 10/25 0/9 3/4 - - -
DAS28f index, medium (3–5)
mean 4.26
12/25 6/9 1/4 - - -
DAS28f index, high (>5)
mean 5.55
3/25 3/9 0/4 - - -
ESRg (mm/h) 56.3 (5–87) 10.3 (1–25)
CRPh (mg/dl) 4.3 (0.4–7.5) 0.27 (0–0.6)
NSAIDi (+/−) 8/25 14/18
Corticosteroids (+/−) 14/25 0/18
DMARDsj (+/−) 25/25 0/18
PBMCsk (106/ml) 1.8 (1.4–2.3) 1.6 (1.3–1.9)
SFMCsl 6.2 (3.6–11.3) *105/ml 9.2 (4.6–18.2) *104/ml
SMMCsm 3.2 *106 1.3 *106
  1. a PB peripheral blood, b SF synovial fluid, c SM synovial membrane, d RF rheumatoid factor, e ACPA anti-citrullinated protein antibody, f DAS28 disease activity score based on 28 joint counts, g ESR erythrocyte sedimentation rate, h CRP C-reactive protein (CRP), i NSAIDs non-steroidal anti-inflammatory drugs, j DMARDs disease-modifying anti-rheumatic drugs, k PBMCs peripheral blood mononuclear cells, l SFMCs synovial fluid mononuclear cells, m SMMCs synovial membrane mononuclear cells. *Mean, (values range). dRF nephelometry assay, cutoff value >15 UI/ml. All patients with RA had high positive dRF levels (more than three times the ULN for the laboratory and assay): 264 ± 190. eACPA: QUANTA Lite® CCP3.1 IgG/IgA ELISA (INOVA Diagnostics), cutoff value >20 UI/ml. All patients with RA had high positive eACPA levels (more than three times the ULN for the laboratory and assay):125 ± 64. hCRP cutoff value 1 mg/dl.