Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis

Table 3 Summary of peripheral immune cell frequencies in healthy donors

	BMI <20 (n = 40)	20 < BMI <25 (n = 51)	BMI >25 (n = 8)	P value
CD4⁺ T cells (%)
Total	40.1 ± 9.55	40.0 ± 9.17	35.7 ± 5.32	0.46
Naive T cells	57.9 ± 12.4	51.6 ± 10.3	48.3 ± 15.1	0.056
Memory T cells	30.6 ± 10.0	34.0 ± 7.97	36.5 ± 9.77	0.077
CD25⁺Treg cells	2.83 ± 1.16	3.51 ± 1.41	3.75 ± 1.92	0.069
Follicular helper T cells	9.43 ± 3.63	11.9 ± 3.91	12.7 ± 6.35	0.083
Th1 cells	7.25 ± 3.03	7.79 ± 2.86	8.85 ± 3.37	0.34
Th2 cells	8.12 ± 3.61	8.80 ± 3.72	9.47 ± 4.72	0.54
Th17 cells	7.05 ± 2.83	8.51 ± 2.75	8.41 ± 1.92	0.066
Th17.1 cells	7.94 ± 4.72	8.87 ± 4.01	9.79 ± 6.88	0.46
B cells (%)
Total	4.73 ± 2.91	5.15 ± 2.69	6.15 ± 2.14	0.39
Naive B cells	54.9 ± 14.6	53.5 ± 17.0	66.0 ± 11.4	0.12
Switch- memory B cells	10.4 ± 5.12	10.1 ± 4.11	8.01 ± 2.21	0.38
Switch⁺memory B cells	27.1 ± 11.6	27.5 ± 11.6	19.5 ± 7.69	0.18
Double negative B cells	7.64 ± 4.33	8.17 ± 6.65	6.48 ± 2.75	0.70
Plasmablast	4.11 ± 7.73	3.19 ± 3.78	2.16 ± 1.73	0.59
Monocytes (%)
CD14⁺CD16−	90.7 ± 4.93	89.7 ± 4.75	88.2 ± 5.93	0.39
CD14⁺CD16+	2.02 ± 1.23	2.31 ± 1.26	3.05 ± 2.57	0.15
CD14^midCD16+	6.78 ± 3.69	7.33 ± 3.87	7.90 ± 3.39	0.67

The percentages of total CD4⁺ T cells and B cells are shown as a ratio to the total number of lymphocytes. The percentages of cell subsets are shown as a ratio to total CD4⁺ T cells, B cells, and monocytes. Data are shown as mean +/− SD. BMI body mass index, Treg T regulatory cells, Th T helper. Differences were analyzed by one-way analysis of variance: *p < 0.05

ISSN: 1478-6362