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Table 1 Disease features and biopsy sites in patients with granulomatosis with polyangiitis

From: M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

Variables Results (n = 35)
Age, years 48.9 ± 12.6
Female, n (%) 22 (62.9)
Disease status
 Onset, n (%) 9 (25.7)
 Relapse, n (%) 25 (71.4)
 Persistent disease, n (%) 1 (2.8)
Years since diagnosisa 8.7 ± 5.6
Disease extension
 Localized disease, n (%) 29 (82.9)
 Generalized disease, n (%) 6 (17.1)
Disease manifestations
 ENT involvement, n (%) 34 (97.1)
 Eye disease, n (%) 8 (22.8)
 Lung involvement, n (%) 7 (20.0)
 Glomerulonephritis, n (%) 4 (11.4)
 Cutaneous vasculitis, n (%) 1 (2.8)
ANCA positivity
 cANCA by IIF, n (%) 33 (94.3)
 PR3-ANCA by ELISA, n (%) 32 (91.4)
Biopsy sites
 Nose, n (%) 28 (80.0)
 Other sites, n (%) 7 (20.0)
Staphylococcus aureus
 Positive culture, n (%)b 19 (55.9)
Therapy
 No therapy, n (%) 13 (37.1)
 Prednisolone, n (%) 10 (28.6)
 Prednisolone daily dose, mg 11.2 (9.3–20.0)
 Daily co-trimoxazole, n (%) 14 (40.0)
 Cyclophosphamide, n (%) 4 (11.4)
 Azathioprine, n (%) 4 (11.4)
 Methotrexate, n (%) 1 (2.8)
 Mycophenolate mofetil, n (%) 4 (11.4)
 Cyclosporin A, n (%) 1 (2.8)
  1. Continuous variables are presented as mean and standard deviation or as median and interquartile range as appropriate. ANCA antineutrophil cytoplasmic antibodies, ELISA enzyme-linked immunosorbent assay, ENT ear, nose and throat, IIF indirect immunofluorescence, n number of patients, PR3 proteinase 3. aYears since diagnosis includes patients with relapsing and persistent disease. bResults of nasal swab cultures were available for 34 patients