Fig. 2

Fold-changes in expression for genes differentially expressed (third trimester [T3] vs baseline [T0]) among women who improved, but not among those who worsened. Fold-changes in expression are plotted for women who improved during pregnancy (y-axis) and women who worsened during pregnancy (x-axis) only for those genes that were differentially expressed (T3 vs T0) in the “improved” group (q<0.05) and not in the “worsened” group. Only genes with FC≥2 are shown. Fold-changes for genes that were under- expressed at T3 are shown as negative values. The majority of genes showed similar expression changes in both groups of women with RA, as shown by the gray dots around the y = x line (solid line). A small cluster of genes (black triangles), however, was over-expressed among women who improved and under-expressed among women who worsened. Genes in this cluster were IFI44, IFI44L, IFIT1, HERC5, CMPK2, RSAD2, and SIGLEC1