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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Fig. 1

Early onset of joint inflammation in the MIA model of OA. a Knee joint diameter was significantly increased on days 1, 3 and 10 compared with saline control. b Joint blood flow increased on day 1, but subsequently was not significantly different from control joints. c Leukocyte rolling was augmented on day 1 and then returned to control levels thereafter. d Leukocyte adherence within synovial post-capillary venules was significantly increased on day 1, but gradually returned to control over the succeeding days. ****P < 0.0001, *P < 0.05 two-way ANOVA with Bonferroni post-hoc test; n = 4–28. Data presented as mean ± SEM. i.artic. intra-articular, MIA monoiodoacetate

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