Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Table 3 Association between baseline systemic bone mineral density and progression of tibiofemoral cartilage defects

	Univariable analysis Odds ratio (95% CI)	P	Multivariable analysis^a Odds ratio (95% CI)	P
Total body BMD
Medial	1.25 (0.80, 1.94)	0.33	1.71 (0.94, 3.08)	0.08
Lateral	1.19 (0.78, 1.81)	0.42	1.45 (0.84, 2.50)	0.18
Spine BMD
Medial	1.38 (1.07, 1.77)	0.01	1.45 (1.10, 1.91)	0.01
Lateral	1.19 (0.94, 1.52)	0.15	1.30 (1.00, 1.67)	0.049
Total hip BMD
Medial	1.33 (1.00, 1.75)	0.05	1.63 (1.10, 2.41)	0.02
Lateral	1.22 (0.93, 1.59)	0.15	1.53 (1.08, 2.18)	0.02

BMD (bone mineral density) was assessed in g/10 cm² so that one unit change in BMD approximated one standard deviation change in BMD. ^aAdjusted for gender, baseline age, body mass index, strenuous physical activity, respective baseline tibial cartilage volume and bone area, and time between scans

ISSN: 1478-6362