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Table 6 Association of baseline systemic bone mineral density with progression of tibiofemoral cartilage defects and annual percentage tibial cartilage volume loss, stratified by obesity status

From: Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

  Multivariable analysisa
Odds ratio (95% CI)
Non-obese
P Multivariable analysisa
Odds ratio (95% CI)
Obese
P
Progression of tibiofemoral cartilage defects
 Total body BMD
  Medial 2.20 (0.65, 7.42) 0.20 2.26 (0.95, 5.37) 0.07
  Lateral 1.25 (0.54, 2.89) 0.61 1.43 (0.66, 3.08) 0.37
 Spine BMD
  Medial 1.72 (0.92, 3.21) 0.09 2.02 (1.24, 3.29) 0.01
  Lateral 1.30 (0.83, 2.02) 0.25 1.13 (0.77, 1.65) 0.52
 Total hip BMD
  Medial 2.53 (1.01, 6.32) 0.048 1.71 (1.01, 2.89) 0.047
  Lateral 1.52 (0.86, 2.69) 0.15 1.46 (0.90, 2.36) 0.12
  Multivariable analysisb
Regression coefficient (95% CI)
Non-obese
P Multivariable analysisb
Regression coefficient (95% CI)
Obese
P
Annual tibial cartilage volume loss (%)
 Total body BMD
 Medial 0.05 (−0.40, 0.49) 0.83 0.30 (−0.29, 0.89) 0.31
 Lateral 0.53 (0.14, 0.92) 0.01 0.68 (0.19, 1.18) 0.01
 Spine BMD
  Medial 0.05 (−0.18, 0.29) 0.66 0.11 (−0.16, 0.38) 0.42
  Lateral 0.19 (−0.02, 0.41) 0.08 0.30 (0.06, 0.54) 0.02
 Total hip BMD
  Medial 0.02 (−0.26, 0.30) 0.88 0.12 (−0.21, 0.44) 0.47
  Lateral 0.27 (0.02, 0.53) 0.03 0.48 (0.21, 0.75) 0.001
  1. Bone mineral density (BMD) was assessed in g/10 cm2 so that one unit change in BMD approximated one standard deviation change in BMD. aAdjusted for gender, baseline age, body mass index, strenuous physical activity, respective baseline tibial cartilage volume and bone area, and time between scans. bAdjusted for ender, baseline age, body mass index, strenuous physical activity, and respective tibial bone area