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Table 6 Association of baseline systemic bone mineral density with progression of tibiofemoral cartilage defects and annual percentage tibial cartilage volume loss, stratified by obesity status

From: Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

 

Multivariable analysisa

Odds ratio (95% CI)

Non-obese

P

Multivariable analysisa

Odds ratio (95% CI)

Obese

P

Progression of tibiofemoral cartilage defects

 Total body BMD

  Medial

2.20 (0.65, 7.42)

0.20

2.26 (0.95, 5.37)

0.07

  Lateral

1.25 (0.54, 2.89)

0.61

1.43 (0.66, 3.08)

0.37

 Spine BMD

  Medial

1.72 (0.92, 3.21)

0.09

2.02 (1.24, 3.29)

0.01

  Lateral

1.30 (0.83, 2.02)

0.25

1.13 (0.77, 1.65)

0.52

 Total hip BMD

  Medial

2.53 (1.01, 6.32)

0.048

1.71 (1.01, 2.89)

0.047

  Lateral

1.52 (0.86, 2.69)

0.15

1.46 (0.90, 2.36)

0.12

 

Multivariable analysisb

Regression coefficient (95% CI)

Non-obese

P

Multivariable analysisb

Regression coefficient (95% CI)

Obese

P

Annual tibial cartilage volume loss (%)

 Total body BMD

 Medial

0.05 (−0.40, 0.49)

0.83

0.30 (−0.29, 0.89)

0.31

 Lateral

0.53 (0.14, 0.92)

0.01

0.68 (0.19, 1.18)

0.01

 Spine BMD

  Medial

0.05 (−0.18, 0.29)

0.66

0.11 (−0.16, 0.38)

0.42

  Lateral

0.19 (−0.02, 0.41)

0.08

0.30 (0.06, 0.54)

0.02

 Total hip BMD

  Medial

0.02 (−0.26, 0.30)

0.88

0.12 (−0.21, 0.44)

0.47

  Lateral

0.27 (0.02, 0.53)

0.03

0.48 (0.21, 0.75)

0.001

  1. Bone mineral density (BMD) was assessed in g/10 cm2 so that one unit change in BMD approximated one standard deviation change in BMD. aAdjusted for gender, baseline age, body mass index, strenuous physical activity, respective baseline tibial cartilage volume and bone area, and time between scans. bAdjusted for ender, baseline age, body mass index, strenuous physical activity, and respective tibial bone area