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Table 2 Incidence rates of ACS, stroke and VTE in AS, PsA, uSpA patients and GP comparators

From: Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

 

AS

PsA

uSpA

GP

Acute coronary syndrome

 Subjects at risk, n

6192

15,487

5096

257,721

 Incident events, n (male/female)

143 (125/18)

420 (242/178)

59 (39/20)

5480 (3645/1835)

 Person-years at risk, n

34,658

87,903

27,287

1,712,019

Overall incidence rates

 -Crude rates

4.1 (3.4–4.8)

4.8 (4.3–5.2)

2.2 (1.6–2.7)

3.2 (3.1–3.3)

 -Standardized ratesa

4.3 (3.4–5.2)

5.4 (4.8–5.9)

4.7 (3.1–6.2)

 

Male incidence rates

 -Crude rates

5.3 (4.4–6.3)

6.3 (5.5–7.1)

3.3 (2.3–4.3)

4.4 (4.3–4.6)

 -Standardized ratesb

6.3 (5.1–7.5)

7.0 (6.1–8.0)

5.9 (3.7–8.0)

 

Female incidence rates

 -Crude rates

1.6 (0.9–2.3)

3.6 (3.1–4.1)

1.3 (0.7–1.9)

2.1 (2.0–2.2)

 -Standardized ratesb

2.4 (1.0–3.7)

3.8 (3.2–4.4)

3.6 (1.4–5.8)

 

Composite strokec

 Subjects at risk, n

6247

15,536

5106

257,481

 Incident events, n (male/female)

147 (110/37)

463 (219/244)

66 (31/35)

8001 (4405/3596)

 Person-years at risk, n

35,017

88,075

27343

1,707,096

Overall incidence rates

 -Crude rates

4.2 (3.5–4.9)

5.3 (4.8–5.7)

2.4 (1.8–3.0)

4.7 (4.6–4.8)

 -Standardized ratesa

5.4 (4.3–6.6)

5.9 (5.4–6.5)

5.7 (3.9–7.4)

 

Male incidence rates

 -Crude rates

4.6 (3.8–5.5)

5.6 (4.8–6.3)

2.6 (1.7–3.5)

5.3 (5.1–5.4)

 -Standardized ratesb

5.9 (4.7–7.1)

6.5 (5.6–7.3)

5.2 (2.9–7.4)

 

Female incidence rates

 -Crude rates

3.3 (2.2–4.4)

5.0 (4.4–5.6)

2.3 (1.5–3.0)

4.1 (4.0–4.3)

 -Standardized ratesb

5.0 (3.0–6.9)

5.5 (4.7–6.2)

6.1 (3.4–8.8)

 

Venous thromboembolism

 Subjects at risk, n

6333

15,716

5110

262,600

 Incident events, n (male/female)

98 (66/32)

268 (95/173)

56 (26/30)

3925 (2038/1887)

 Person-years at risk, n

35,575

89,525

27,363

1,745,481

Overall incidence rates

 -Crude rates

2.8 (2.2–3.3)

3.0 (2.6–3.4)

2.0 (1.5–2.6)

2.2 (2.2–2.3)

 -Standardized ratesa

3.6 (2.6–4.6)

3.2 (2.8–3.6)

3.5 (2.3–4.7)

 

Male incidence rates

 -Crude rates

2.7 (2.1–3.4)

2.4 (1.9–2.8)

2.2 (1.3–3.0)

2.4 (2.3–2.5)

 -Standardized ratesb

3.0 (2.2–3.8)

2.6 (2.1–3.2)

3.1 (1.8–4.4)

 

Female incidence rates

 -Crude rates

2.8 (1.9–3.8)

3.5 (3.0–4.0)

2.0 (1.3–2.7)

2.1 (2.0–2.2)

 -Standardized ratesb

4.2 (2.4–5.9)

3.7 (3.2–4.3)

3.9 (1.9–5.9)

 
  1. Rates are presented as number of events per 1000 person-years at risk. All rates are calculated with 95% confidence interval given in parenthesis
  2. ACS acute coronary syndrome, VTE venous thromboembolism, AS ankylosing spondylitis, PsA psoriatic arthritis, uSpA undifferentiated spondyloarthritis, GP general population
  3. aAge- and sex-adjusted with the general population (GP) cohort as reference
  4. bAge-adjusted with the GP cohort as reference
  5. cComposite stroke includes ischemic, hemorrhagic, unspecified stroke, and transient ischemic attack