Skip to main content

Table 2 Incidence rates of ACS, stroke and VTE in AS, PsA, uSpA patients and GP comparators

From: Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

  AS PsA uSpA GP
Acute coronary syndrome
 Subjects at risk, n 6192 15,487 5096 257,721
 Incident events, n (male/female) 143 (125/18) 420 (242/178) 59 (39/20) 5480 (3645/1835)
 Person-years at risk, n 34,658 87,903 27,287 1,712,019
Overall incidence rates
 -Crude rates 4.1 (3.4–4.8) 4.8 (4.3–5.2) 2.2 (1.6–2.7) 3.2 (3.1–3.3)
 -Standardized ratesa 4.3 (3.4–5.2) 5.4 (4.8–5.9) 4.7 (3.1–6.2)  
Male incidence rates
 -Crude rates 5.3 (4.4–6.3) 6.3 (5.5–7.1) 3.3 (2.3–4.3) 4.4 (4.3–4.6)
 -Standardized ratesb 6.3 (5.1–7.5) 7.0 (6.1–8.0) 5.9 (3.7–8.0)  
Female incidence rates
 -Crude rates 1.6 (0.9–2.3) 3.6 (3.1–4.1) 1.3 (0.7–1.9) 2.1 (2.0–2.2)
 -Standardized ratesb 2.4 (1.0–3.7) 3.8 (3.2–4.4) 3.6 (1.4–5.8)  
Composite strokec
 Subjects at risk, n 6247 15,536 5106 257,481
 Incident events, n (male/female) 147 (110/37) 463 (219/244) 66 (31/35) 8001 (4405/3596)
 Person-years at risk, n 35,017 88,075 27343 1,707,096
Overall incidence rates
 -Crude rates 4.2 (3.5–4.9) 5.3 (4.8–5.7) 2.4 (1.8–3.0) 4.7 (4.6–4.8)
 -Standardized ratesa 5.4 (4.3–6.6) 5.9 (5.4–6.5) 5.7 (3.9–7.4)  
Male incidence rates
 -Crude rates 4.6 (3.8–5.5) 5.6 (4.8–6.3) 2.6 (1.7–3.5) 5.3 (5.1–5.4)
 -Standardized ratesb 5.9 (4.7–7.1) 6.5 (5.6–7.3) 5.2 (2.9–7.4)  
Female incidence rates
 -Crude rates 3.3 (2.2–4.4) 5.0 (4.4–5.6) 2.3 (1.5–3.0) 4.1 (4.0–4.3)
 -Standardized ratesb 5.0 (3.0–6.9) 5.5 (4.7–6.2) 6.1 (3.4–8.8)  
Venous thromboembolism
 Subjects at risk, n 6333 15,716 5110 262,600
 Incident events, n (male/female) 98 (66/32) 268 (95/173) 56 (26/30) 3925 (2038/1887)
 Person-years at risk, n 35,575 89,525 27,363 1,745,481
Overall incidence rates
 -Crude rates 2.8 (2.2–3.3) 3.0 (2.6–3.4) 2.0 (1.5–2.6) 2.2 (2.2–2.3)
 -Standardized ratesa 3.6 (2.6–4.6) 3.2 (2.8–3.6) 3.5 (2.3–4.7)  
Male incidence rates
 -Crude rates 2.7 (2.1–3.4) 2.4 (1.9–2.8) 2.2 (1.3–3.0) 2.4 (2.3–2.5)
 -Standardized ratesb 3.0 (2.2–3.8) 2.6 (2.1–3.2) 3.1 (1.8–4.4)  
Female incidence rates
 -Crude rates 2.8 (1.9–3.8) 3.5 (3.0–4.0) 2.0 (1.3–2.7) 2.1 (2.0–2.2)
 -Standardized ratesb 4.2 (2.4–5.9) 3.7 (3.2–4.3) 3.9 (1.9–5.9)  
  1. Rates are presented as number of events per 1000 person-years at risk. All rates are calculated with 95% confidence interval given in parenthesis
  2. ACS acute coronary syndrome, VTE venous thromboembolism, AS ankylosing spondylitis, PsA psoriatic arthritis, uSpA undifferentiated spondyloarthritis, GP general population
  3. aAge- and sex-adjusted with the general population (GP) cohort as reference
  4. bAge-adjusted with the GP cohort as reference
  5. cComposite stroke includes ischemic, hemorrhagic, unspecified stroke, and transient ischemic attack