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Table 3 Mean (SD) cumulative levels of aggrecan fragments detected in medium after 16 days of culture

From: Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

FFGV (ng/μg sGAG) Condition A Condition B Condition C Condition D
0.326 (0.016) 0.447 (0.036) 1.002 (0.359) 1.506 (0.359)
  P value Norm    
B vs A 0.021 1.37   P value Norm   
C vs A 0.428 3.07 C vs B 0.509 2.24   P value Norm  
D vs A 0.049 4.62 D vs B 0.067 3.37 D vs C 0.744 1.50  
ARGS-CS2 (ng/μg sGAG) Condition A Condition B Condition C Condition D
0.48 (0.036) 0.51 (0.056) 2.10 (1.608) 2.32 (1.134)
  P value Norm    
B vs A 0.193 1.06   P value Norm   
C vs A 0.254 4.38 C vs B 0.255 4.12   P value Norm  
D vs A 0.032 4.83 D vs B 0.033 4.55 D vs C 0.850 1.10  
G1-KEEE (AU/mg sGAG) Condition A Condition B Condition C Condition D
0.909 (0.604) 0.986 (1.028) 9.297 (0.781) 25.118 (13.842)
  P value Norm    
B vs A 0.905 1.08   P value Norm   
C vs A 0.011 10.23 C vs B 0.016 9.43   P value Norm  
D vs A 0.119 27.63 D vs B 0.106 25.47 D vs C 0.298 2.70  
G1–G3 (ng/μg sGAG) Condition A Condition B Condition C Condition D
15.3 (2.75) 23.6 (18.27) 9.8 (1.51) 18.6 (14.59)
  P value Norm    
B vs A 0.460 1.54   P value Norm   
C vs A 0.159 0.64 C vs B 0.351 0.42   P value Norm  
D vs A 0.935 1.22 D vs B 0.199 0.79 D vs C 0.603 1.90  
  1. Abbreviations: FFGV Total levels of FFGV fragments, Norm Normalizing mean values. Conditions: A Uninjured cartilage, B Injured cartilage, C Uninjured cartilage + synovium + joint capsule, D Injured cartilage + synovium + joint capsule
  2. Statistical (using paired samples t test) significance (P < 0.05) or trends (P < 0.1) are shown in bold