Skip to main content

Table 2 Gene ontology (GO) analysis with the 87 transcripts dysregulated between responders and non-responders to abatacept/methotrexate

From: Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

GO accession GO term P value Count in 87 mRNA list Percentage in 87 mRNA list Count in human genome Percentage in human genome Enrichment
Biological process
 GO:1902600 Hydrogen ion transmembrane transport 0.0011 6 10.17 93 0.55 18.38
 GO:0022904 Respiratory electron transport chain 0.0011 6 10.17 99 0.59 17.26
 GO:0022900 Electron transport chain 0.0011 6 10.17 101 0.60 16.92
 GO:0045333 Cellular respiration 0.0011 7 11.86 146 0.87 13.66
 GO:0015992 Proton transport 0.0019 6 10.17 115 0.68 14.86
 GO:0006818 Hydrogen transport 0.0019 6 10.17 117 0.70 14.61
Molecular function
 GO:0015002 Heme-copper terminal oxidase activity 0.0011 4 6.78 23 0.14 49.54
 GO:0004129 Cytochrome-c oxidase activity 0.0011 4 6.78 23 0.14 49.54
 GO:0016676 Oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 0.0011 4 6.78 23 0.14 49.54
 GO:0016675 Oxidoreductase activity, acting on a heme group of donors 0.0011 4 6.78 24 0.14 47.47
 GO:0015078 Hydrogen ion transmembrane transporter activity 0.0011 6 10.17 88 0.52 19.42
Cellular localization
 GO:0070469 Respiratory chain 0.0011 6 10.17 68 0.40 25.13
 GO:0044455 Mitochondrial membrane part 0.0011 7 11.86 144 0.86 13.85
 GO:0005743 Mitochondrial inner membrane 0.0011 10 16.95 350 2.08 8.14
 GO:0019866 Organelle inner membrane 0.0011 10 16.95 390 2.32 7.30
 GO:0005746 Mitochondrial respiratory chain 0.0017 5 8.47 62 0.37 22.97
 GO:0005740 Mitochondrial envelope 0.0017 11 18.64 544 3.24 5.76
 GO:0031966 Mitochondrial membrane 0.0053 10 16.95 508 3.02 5.61
  1. Corrected p values were determined by a standard hypergeometric distribution