Fig. 1
From: Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis
a The SOFUSA™ nanotopographical device. (i) Microfluidic fluid block with a perforated attachment adhesive (tan), microfluidic distributor (green), perforated attachment adhesive (yellow), and silicon microneedle array (gray). Each microneedle is 350 μm long and 110 μm wide, with a 30-μm hole located off-center, through which the drug flows out of a total of 100 microneedles (ii) Scanning electron microscopy (SEM) image of nanotopographic film heat formed over the silicon microneedles (scale bar represents 300 μm); (iii) SEM of individual microneedle, and (iv) SEM image of the nanostructures on each microneedle (scale bar represents 3 μm). b Administration procedure for the SOFUSA™ nanotopographical device. (i) Location of SOFUSA™ on the rat dorsal region during drug delivery experiments; (ii) cross-sectional illustration of the complete SOFUSA™ device, and (iii) microfluidic fluid block as defined in panel a. c Timeline for induction, measurements, and treatments of animals with collagen-induced arthritis