Fig. 5

Isotypes, fine specificity and avidity index of ACPA-positive RA patients at different ages of onset; data from the Leiden EAC. Association between age of onset and ACPA isotypes (a), ACPA fine specificity (b) and ACPA avidity index (c) within RA patients of the Leiden EAC. Horizontal lines represent median values. Each dot represents one patient. ACPA anti-citrullinated protein antibodies