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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Fig. 1

Timeline depicting the induction of arthritis in rats and thereupon methotrexate (MTX) interventions. On day 7 and day 14 the first and second immunization (Im1 and Im2) was administered, on day 19 the delayed type hypersensitivity (DTH) test and thereupon four intra-articular (i.a.) injections were administered. Upon arthritic induction the rats were administered saline (black arrows) or 2× MTX (dark grey arrows) or 4× MTX (light grey arrows). PET-CT (#) was performed before (day 22) and after (day 40) MTX therapy. At the end of the study (day 40), ex-vivo tissue distribution (TD) was performed. Healthy rats did not receive any arthritic induction or MTX treatment and were sacrificed on day 40

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Arthritis Research & Therapy

ISSN: 1478-6362

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