Fig. 3

Effect of lentivirus-mediated heterologous expression of hSPAG11B/C or APC366 on proteolytic balance. a and b. Effect of the synthetic tryptase inhibitor APC366 (10–100 μM) or the transduction with the lentiviruses phSPAG11B/C or pWPXLd-IG, as control, in the tryptase-like activity in the synovial fluid of mouse knee joints 7 days after the induction of arthritis. ^*** P < 0.001 vs. control group; ^# P < 0.05; ^## P < 0.01 vs. arthritis groups; n = 6–8 per group). c and d. Relative expression of Mcpt-6 in the mouse knee joint 7 days after induction of arthritis in animals treated with APC366 or transduced with phSPAG11B/C or pWPXLd-IG. ^* P < 0.05; ^** P < 0.01; ^*** P < 0.001 vs. control groups (n = 5–6 per group). Abbreviation: n.s. not significant