Fig. 6
Effect of lentivirus-mediated heterologous expression of hSPAG11B/C and APC366 on cytokines and chemokine production. a and b. Effect of the synthetic tryptase inhibitor APC366 (10–100 μM) or the knee joint transduction (1 × 107 TU/joint) with phSPAG11B/C in the release of IL-6 (a and b) and CXCL1/KC (c and d) 7 days after the induction of arthritis with mBSA/IL-1β. (N = 6 mice per group). * P < 0.05; ** P < 0.01; *** P < 0.001 vs. control groups; # P < 0.05; ## P < 0.01; ### P < 0.001 vs. arthritis + vehicle groups. Abbreviation: n.s. not significant