High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center

Table 4 Comparisons of the DETECT algorithm and the ESC/ERS 2009 guidelines

	PAH vs no PH patients (n = 63)			Patients with mPAP ≥21 vs mPAP <21mmg (n = 63)			PH vs no PH patients (n = 83)
	PAH (n = 35)	No PH (n = 28)	P value	mPAP ≥21 mmHg (n = 49)	mPAP <21mmg (n = 14)	P value	PH (n = 52)	No PH (n = 31)	P value
DETECT algorithm
Score step 1^b	330.0 (±25.3)	313.7 (±17.5)	<0.01	326.9 (±22.8)	308.6 (±20.8)	<0.01	327.9 (±23.6)	311.8 (±17.6)	<0.01
Indication of Echo^a	35 (100)	24 (85.7)	0.03	49 (100)	10 (71.4)	<0.01	51 (98.1)	24 (77.4)	<0.01
Score step 2^b	60.2 (±11.3)	37.3 (±8.4)	<0.001	54.7 (±13.3)	33.5 (±8.8)	<0.001	56.4 (±12.4)	36.5 (±8.4)	<0.001
RHC recommendation^a	35 (100)	16 (57.1)	<0.001	46 (93.9)	5 (35.7)	<0.001	51 (98.1)	17 (54.8)	<0.001
ESC/ERS 2009 guidelines
RHC recommendation^a	32 (91.4)	4 (14.3)	<0.001	34 (69.4)	2 (14.3)	<0.001	42 (80.8)	4 (12.9)	<0.001

PAH pulmonary arterial hypertension, PH pulmonary hypertension, mPAP mean pulmonary artery pressure, Echo echocardiography, RHC right heart catheterization, ESC/ERS European Society of Cardiology and the European Respiratory Society. ^aData are shown as number (%) for categorical variables. ^bData are shown as mean (± SD)

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