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Table 5 Observation of PAH detection programs

From: High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center

  

RHC referral rate, %

Missed diagnoses, %

Sensitivity %

Specificity %

PPV %

NPV %

PAH vs no PH patients

DETECT algorithm

(95% CI)

51/63, 80.9%

-

0/35, 0%

-

100%

(90.1–100)

42.9%

(26.5–60.9)

68.6%

(55.0–79.7)

100%

(75.7–100)

ESC/ERS guidelines

(95% CI)

36/63, 57.1%

-

3/35, 8.5%

-

91.4%

(77.6–97.0)

85.7%

(68.5–94.3)

88.9%

(74.7–95.6)

88.9%

(71.9–96.1)

Patients with mPAP ≥21 vs mPAP <21mmg

DETECT algorithm

(95% CI)

51/63, 80.9%

-

3/49, 6.1%

-

93.9%

(83.5–97.9)

64.3%

(38.8–83.7)

90.2%

(79.0–95.7)

75.0%

(46.8–91.1)

ESC/ERS guidelines

(95% CI)

36/63, 57.1%

-

15/49, 30.6%

-

69.4%

(55.5–80.5)

85.7%

(60.1–96.0)

94.4%

(81.9–98.5)

44.4%

(27.6–62.7)

PH vs no PH patients

DETECT algorithm

(95% CI)

68/83, 81.9%

-

1/52, 1.9%

-

98.1%

(89.9–99.7)

45.2%

(29.2–62.2)

75.0%

(63.6–83.8)

93.3%

(70.2–98.8)

ESC/ERS guidelines

(95% CI)

46/83, 55.4%

-

10/52, 19.2%

-

80.8%

(68.1–89.2)

87.1%

(71.1–94.9)

91.3%

(79.7–96.6)

73.0%

(57.0–84.6)

  1. Data shown as number (%). RHC right heart catheterization, PPV positive predictive value, NPV negative positive value, PAH pulmonary arterial hypertension, PH pulmonary hypertension, CI confidence interval, mPAP mean pulmonary artery pressure, ESC/ERS European Society of Cardiology and the European Respiratory Society