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Table 1 Thirteen different approaches tested based on prior simulation results [2]

From: Drug safety analyses in a rheumatoid arthritis registry: application of different approaches regarding timing of exposure and confounder measurement

Approaches for DAS28-CRP adjustment

Description

1. No adjustment

No inclusion of any DAS28-CRP values.

2. Most recent prior measurement

Adjust for most recent DAS28-CRP value prior to start of treatment.

3. Most recent after measurement

Adjust for most recent DAS28-CRP value after start of treatment.

4. Arithmetic mean

Adjust for the arithmetic mean of the two nearest DAS28-CRP measurements.

5. Nearest measurement

Adjust for nearest DAS28-CRP measurement.

6. Weighted mean

Adjust for the weighted mean of the two nearest DAS28-CRP measurements, accounting for proximity.

7. Restricted to within 4 months

Only include subjects with DAS28-CRP within 4 months of start of treatment, prior or post.

8. Restricted to within 2 months

Only include subjects with DAS28-CRP within 2 months of start of treatment, prior or post.

9. Restricted to within 10 months prior

Only include subjects with DAS28-CRP within 10 months prior to start of treatment.

10. Restricted to within 8 months prior

Only include subjects with DAS28-CRP within 8 months prior to start of treatment.

11. Restricted to within 6 months prior

Only include subjects with DAS28-CRP within 6 months prior to start of treatment.

12. Restricted to within 4 months prior

Only include subjects with DAS28-CRP within 4 months prior to start of treatment.

13. Restricted to within 2 months prior

Only include subjects with DAS28-CRP within 2 months prior to start of treatment.

  1. DAS28-CRP disease activity score based on 28 joints - C-reactive protein