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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

Fig. 3

Collagen synthesis mediated by the inflammasome requires miR-155. a Hydroxyproline levels were measured in the culture media from B6 fibroblasts and miR-155-deficient fibroblasts (miR-155KO) + 10 μM bleomycin (Bleo) after 48 h. b Culture media hydroxyproline levels from miR-155KO fibroblasts transduced with the control (Ctl) vector or the miR-155 expressing vector + 10 μM Bleo after 48 h. Data for both a and b are presented as the average from two independent experiments with three replicates (n = 6 for each condition) + SEM using the Mann-Whitney t test. ns Not significant

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