TY - JOUR AU - Takegami, Norihiko AU - Akeda, Koji AU - Yamada, Junichi AU - Sano, Tomohiko AU - Murata, Koichiro AU - Huang, Jenny AU - Masuda, Koichi AU - Sudo, Akihiro PY - 2017 DA - 2017/06/02 TI - RANK/RANKL/OPG system in the intervertebral disc JO - Arthritis Research & Therapy SP - 121 VL - 19 IS - 1 AB - The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has not been examined in detail. The purposes of this study were to examine the expression of the RANK/RANKL/OPG system and to evaluate the function of RANKL in the matrix metabolism of the rat IVD. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-017-1332-y DO - 10.1186/s13075-017-1332-y ID - Takegami2017 ER -