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Table 1 Baseline characteristics and clinical features of CBP patients in the SPACE (n = 438) and DESIR cohorts (n = 647)

From: Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Characteristic

SPACE n = 438

DESIR n = 647

Age, years

31.3 (8.3)

33.6 (8.6)

Symptom duration, months

13.4 (7.4)

18.1 (10.5)

Male

165 (38)

305 (47)

IBP

286 (66)

647 (100)*

Good response to NSAIDsa

181/420 (43)

515/643 (80)

Past history or current symptoms

 Peripheral arthritis

64 (15)

363 (56)

 Dactylitis

24 (6)

83 (13)

 Enthesitis

89 (20)

312 (48)

 AAU

34 (8)

51 (8)

 IBD

34 (8)

23 (4)

 Psoriasis

51 (12)

97 (15)

Elevated CRP (mg/L)/ESR (mm)b

123 (28)

254 (39)

HLA-B27 positive

174/436 (40)

376/646 (58)

Sacroiliitis, radiographyc

48/434 (11)

172 (27)

Sacroiliitis, MRIc

135/431 (31)

207/636 (33)

ASAS criteria for axSpA

203 (46)

410/634 (65)

Any positive family historyd

185 (42)

249 (39)

PFH of AS

90 (21)

127 (20)

PFH of AAU

27 (6)

29 (5)

PFH of ReA

14 (3)

6 (1)

PFH of IBD

33 (8)

32 (5)

PFH of Psoriasis

83 (19)

129 (20)

Total number of SpA diseases in first- or second-degree relatives

 Number of patients with 1 disease

135 (73)

189 (76)

 Number of patients with 2 diseases

39 (21)

47 (19)

 Number of patients with ≥3 diseases

11 (6)

13 (5)

  1. Unless specified otherwise, results are presented as mean ± SD or number (%)
  2. *Inclusion criterion
  3. aBack pain not present anymore or is much better 24–48 hours after a full dose of NSAID
  4. bValues greater than the upper limit of normal
  5. cImaging based on local reading. of sacroiliac joints
  6. dPresence in first- or second-degree relatives of any of the following: AS, AAU, ReA, IBD, or psoriasis
  7. AAU acute anterior uveitis, AS ankylosing spondylitis, ASAS axSpA criteria, Assessment of Spondyloarthritis international Society criteria for axial Spondyloarthritis, CBP chronic back pain, CRP C-reactive protein, ESR erythrocyte sedimentation rate, HLA-B27 human leucocyte antigen B27, IBD inflammatory bowel disease, IBP inflammatory back pain, MRI magnetic resonance imaging, NSAID non-steroidal anti-inflammatory drug, PFH positive family history, ReA reactive arthritis, SpA spondyloarthritis