Skip to main content

Table 1 Baseline characteristics and clinical features of CBP patients in the SPACE (n = 438) and DESIR cohorts (n = 647)

From: Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Characteristic SPACE n = 438 DESIR n = 647
Age, years 31.3 (8.3) 33.6 (8.6)
Symptom duration, months 13.4 (7.4) 18.1 (10.5)
Male 165 (38) 305 (47)
IBP 286 (66) 647 (100)*
Good response to NSAIDsa 181/420 (43) 515/643 (80)
Past history or current symptoms
 Peripheral arthritis 64 (15) 363 (56)
 Dactylitis 24 (6) 83 (13)
 Enthesitis 89 (20) 312 (48)
 AAU 34 (8) 51 (8)
 IBD 34 (8) 23 (4)
 Psoriasis 51 (12) 97 (15)
Elevated CRP (mg/L)/ESR (mm)b 123 (28) 254 (39)
HLA-B27 positive 174/436 (40) 376/646 (58)
Sacroiliitis, radiographyc 48/434 (11) 172 (27)
Sacroiliitis, MRIc 135/431 (31) 207/636 (33)
ASAS criteria for axSpA 203 (46) 410/634 (65)
Any positive family historyd 185 (42) 249 (39)
PFH of AS 90 (21) 127 (20)
PFH of AAU 27 (6) 29 (5)
PFH of ReA 14 (3) 6 (1)
PFH of IBD 33 (8) 32 (5)
PFH of Psoriasis 83 (19) 129 (20)
Total number of SpA diseases in first- or second-degree relatives
 Number of patients with 1 disease 135 (73) 189 (76)
 Number of patients with 2 diseases 39 (21) 47 (19)
 Number of patients with ≥3 diseases 11 (6) 13 (5)
  1. Unless specified otherwise, results are presented as mean ± SD or number (%)
  2. *Inclusion criterion
  3. aBack pain not present anymore or is much better 24–48 hours after a full dose of NSAID
  4. bValues greater than the upper limit of normal
  5. cImaging based on local reading. of sacroiliac joints
  6. dPresence in first- or second-degree relatives of any of the following: AS, AAU, ReA, IBD, or psoriasis
  7. AAU acute anterior uveitis, AS ankylosing spondylitis, ASAS axSpA criteria, Assessment of Spondyloarthritis international Society criteria for axial Spondyloarthritis, CBP chronic back pain, CRP C-reactive protein, ESR erythrocyte sedimentation rate, HLA-B27 human leucocyte antigen B27, IBD inflammatory bowel disease, IBP inflammatory back pain, MRI magnetic resonance imaging, NSAID non-steroidal anti-inflammatory drug, PFH positive family history, ReA reactive arthritis, SpA spondyloarthritis