Fig. 3

Heat map showing canonical pathway groupings for molecular and cellular functions altered in the synovial fluid of responders (a) and non-responders (b) at Stage I compared to Stage II of ACI, identified using Ingenuity analysis, based on proteins which were identified using label-free quantification proteomics (≥1.2-FC). Squares are coloured based on their z score, with orange being up at Stage II and blue being down at Stage II; the colour intensity indicates the prediction strength. The z score represents whether the up- or downregulation of the proteins within that function will lead to activation (positive z score) or inhibition (negative z score) of the function. Black boxes are shown around functions of biological interest: cellular movement, haematological system development and function, immune cell trafficking, and inflammatory response