Table 2 Fold-change of proteins that are differentially expressed in the synovial fluid collected at Stage I compared to Stage II of the ACI procedure in clinical non-responders. Proteins shown in italic were validated using enzyme linked immunosorbant assay
Protein | Fold change | |
|---|---|---|
Description | Accession | |
Perilipin-4 | Q96Q06 | –4.3 |
Syntaxin-7 | O15400 | –3.9 |
Fermitin family homolog 3 | Q86UX7 | –3.7 |
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Q9Y3Z3 | –3.7 |
PDZ and LIM domain protein 1 | O00151 | –3.6 |
Sorting nexin-5 | Q9Y5X3 | –3.3 |
Neuroblast differentiation-associated protein AHNAK | Q09666 | –3.2 |
Signal recognition particle 14 kDa protein | P37108 | –3.0 |
Hyaluronan and proteoglycan link protein 3 | Q96S86 | –3.0 |
Heterogeneous nuclear ribonucleoprotein K | P61978 | –2.9 |
ATP-citrate synthase | P53396 | –2.9 |
Fatty acid-binding protein, epidermal | Q01469 | –2.8 |
60S ribosomal protein L12 | P30050 | –2.7 |
Fatty acid-binding protein, adipocyte | P15090 | –2.6 |
Insulin-like growth factor-binding protein 6 | P24592 | –2.6 |
Protein canopy homolog 3 | Q9BT09 | –2.6 |
Tripeptidyl-peptidase 1 | O14773 | –2.5 |
PDZ and LIM domain protein 3 | Q53GG5 | –2.5 |
Cellular nucleic acid-binding protein | P62633 | –2.5 |
Bifunctional glutamate/proline-tRNA ligase | P07814 | –2.5 |
Protein disulfide-isomerase A3 | P30101 | –2.4 |
Peroxiredoxin-6 | P30041 | –2.4 |
Tryptase alpha/beta-1 | Q15661 | –2.4 |
Endoplasmic reticulum resident protein 29 | P30040 | –2.4 |
Peroxiredoxin-1 | Q06830 | –2.4 |
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | O14745 | –2.4 |
Mitochondrial import inner membrane translocase subunit TIM14 | Q96DA6 | –2.4 |
Mortality factor 4-like protein 1 | Q9UBU8 | –2.4 |
Fructose-bisphosphate aldolase A | P04075 | –2.3 |
Microtubule-associated protein RP/EB family member 1 | Q15691 | –2.3 |
Leucine zipper transcription factor-like protein 1 | Q9NQ48 | –2.3 |
Transcription elongation factor A protein 1 | P23193 | –2.3 |
2',3'-cyclic-nucleotide 3'-phosphodiesterase | P09543 | –2.3 |
Histamine N-methyltransferase | P50135 | –2.3 |
Protein S100-A13 | Q99584 | –2.3 |
Acrosomal protein SP-10 | P26436 | –2.2 |
AP-2 complex subunit beta | P63010 | –2.2 |
S-phase kinase-associated protein 1 | P63208 | –2.2 |
High mobility group protein B3 | O15347 | –2.2 |
Cytokine-like protein 1 | Q9NRR1 | –2.2 |
Mitochondrial fission 1 protein | Q9Y3D6 | –2.2 |
Filamin-A | P21333 | –2.2 |
Nuclear migration protein nudC | Q9Y266 | –2.1 |
Cathepsin K | P43235 | –2.1 |
Prostaglandin E synthase 3 | Q15185 | –2.1 |
Vinculin | P18206 | –2.1 |
Plastin-2 | P13796 | –2.1 |
Coronin-1C | Q9ULV4 | –2.1 |
Ig heavy chain V-I region V35 | P23083 | –2.1 |
Stress-induced-phosphoprotein 1 | P31948 | –2.1 |
Putative phospholipase B-like 2 | Q8NHP8 | –2.1 |
Gelsolin | P06396 | –2.0 |
Spectrin beta chain, erythrocytic | P11277 | –2.0 |
Stathmin | P16949 | –2.0 |
Hsc70-interacting protein | P50502 | –2.0 |
40S Ribosomal protein | P23396 | –2.0 |
Epidermal growth factor receptor substrate 15 | P42566 | 22.5 |
Hemoglobin subunit theta-1 | P09105 | 6.1 |
C-type lectin domain family 11 member A | Q9Y240 | 5.6 |
Periostin | Q15063 | 5.1 |
Collagen alpha-1(I) chain | P02452 | 4.7 |
Spectrin alpha chain, erythrocytic 1 | P02549 | 4.0 |
Collagen alpha-1(V) chain | P20908 | 3.7 |
Fibrinogen gamma chain | P02679 | 3.5 |
Collagen alpha-1(XII) chain | Q99715 | 3.3 |
Complement C1q tumor necrosis factor-related protein 3 | Q9BXJ4 | 3.1 |
Adiponectin | Q15848 | 3.0 |
Adipocyte enhancer-binding protein 1 | Q8IUX7 | 3.0 |
Latent-transforming growth factor beta-binding protein 1 | Q14766 | 3.0 |
Fibrinogen beta chain | P02675 | 3.0 |
Chondroitin sulfate proteoglycan 4 | Q6UVK1 | 2.9 |
Fibrinogen alpha chain | P02671 | 2.8 |
Interstitial collagenase (MMP1) | P03956 | 2.7 |
Secreted phosphoprotein 24 | Q13103 | 2.7 |
Collagen alpha-2(V) chain | P05997 | 2.6 |
Ferritin light chain | P02792 | 2.6 |
C4b-binding protein alpha chain | P04003 | 2.6 |
Nucleobindin-1 | Q02818 | 2.4 |
C4b-binding protein beta chain | P20851 | 2.2 |
Vitamin K-dependent protein S | P07225 | 2.2 |
Fibronectin | P02751 | 2.2 |
Prosaposin | P07602 | 2.1 |
Integrin beta-like protein 1 | O95965 | 2.1 |
Adipocyte plasma membrane-associated protein | Q9HDC9 | 2.1 |
Cytoplasmic dynein 1 heavy chain 1 | Q14204 | 2.0 |
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D | A1L4H1 | 2.0 |
F-actin-capping protein subunit beta | P47756 | 2.0 |
Mannan-binding lectin serine protease 1 | P48740 | 2.0 |
Thrombospondin-3 | P49746 | 2.0 |