Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders—findings of a multicenter population-based study

Table 3 Age and sex-adjusted odds ratios for the cardiovascular and metabolic disorders assessed (results of the four mixed-effects logistic regression models)

	Obesity^a		Diabetes^b		Hypertension^a		Elevated blood cholesterol and/or lipids^b
	AOR (95% CI)	p value^c	AOR (95% CI)	p value^c	AOR (95% CI)	p value^c	AOR (95% CI)	p value^c
ANA positivity		0.99		0.73		0.66		0.71
Negative (n = 756)	Reference		Reference		Reference		Reference
Weakly positive (n = 320)	0.98 (0.71–1.35)		0.86 (0.49–1.50)		0.72 (0.47–1.10)		1.13 (0.83–1.53)
Moderately or strongly positive (n = 53)	1.00 (0.50–1.97)		0.66 (0.19–2.28)		1.00 (0.45–2.23)		0.94 (0.50–1.77)

ANA anti-nuclear autoantibody, AOR adjusted odds ratio, BMI body mass index, CI confidence interval
^aObjectively measured weight and height and blood pressure (see Methods). Obesity was defined as BMI ≥ 30 kg/m². Hypertension was defined as a systolic or diastolic blood pressure ≥ 140 mmHg and/or 90 mmHg, respectively
^bSelf-reported information
^cTests of fixed effects

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