Skip to main content
Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route

Fig. 6

Proposed working model for the role of HMGB1 in anti-MPO antibody-induced GEnC injury. HMGB1 could increase the expression of moesin on GEnCs and further the binding of anti-MPO antibody to GEnCs due to the cross-reaction of anti-MPO antibody to moesin. In such circumstances, GEnCs could be activated and sequentially be damaged. HMGB1 high mobility group box-1, LDH lactate dehydrogenase, MPO myeloperoxidase, RAGE receptor for advanced glycation end product, sICAM-1 soluble intercellular cell adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, TLR Toll-like receptor

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us