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Table 3 Patient-reported outcomes in patients with SSc-PAH compared to patients with SSc without PAH

From: Survival and quality of life in incident systemic sclerosis-related pulmonary arterial hypertension

Outcomes PAH No PAH P value
SHAQ domaina
Patient number 132 1447  
 Total score 3.2 ± 1.7 3.3 ± 2.1 0.74
 Breathing 4.9 ± 2.5 2.3 ± 2.4 <0.001
 Digital ulcers 1.9 ± 2.5 1.4 ± 2.4 0.02
 Intestinal 2.8 ± 2.5 2.2 ± 2.4 0.002
 Patient global assessment 5.1 ± 2.2 3.6 ± 2.4 <0.001
 Pain 3.9 ± 2.6 3.4 ± 2.6 0.03
 Vascular (RP) 3.3 ± 2.5 2.7 ± 2.5 0.01
SF-36 domainb
 Physical functioning 35.7 ± 23.8 57.5 ± 28.9 <0.001
 Role limitation, physical 27.2 ± 39.1 49.2 ± 43.4 <0.001
 Role limitation, emotional 55.9 ± 44.9 67.3 ± 40.4 0.05
 Social functioning 64.2 ± 27.7 70.5 ± 26.9 0.07
 Mental health 66.1 ± 21.1 68.9 ± 20.2 0.28
 Energy/vitality 38.6 ± 22.2 47.1 ± 24.1 0.01
 Bodily pain 55.3 ± 28.8 60.7 ± 27.9 0.10
 General health perception 36.6 ± 20.5 46.2 ± 22.7 0.01
 Physical component score 31.7 ± 8.7 38.9 ± 11.6 <0.001
 Mental component score 46.3 ± 10.7 46.3 ± 10.4 0.48
  1. Systemic sclerosis (SSc)-specific health assessment questionnaire (SHAQ) and Medical Outcomes Study Short Form-36 (SF-36) values are based on the average of all instrument scores collected annually in the database. For those with pulmonary hypertension (PAH), this includes only those scores that have been collected since PAH diagnosis. For those without PAH this includes all scores within the database for these patients. Raynaud's phenomenon (RP)
  2. aThe SHAQ is a generic instrument measuring functional outcome validated for use in SSc. The score ranges from 0 to 10, with 0 being no functional limitation and 10 being severe functional limitation
  3. bThe SF-36 form is a 36-item scale that measures eight domains of health status. The final score is standardised to the general population normative score of 50. The final score for each domain lies between 0 and 100, with 0 being the worst possible health and 100 the best possible health