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Table 1 Disease activity parameters of patients in DAS28-CRP or DAS28-ESR remission, but not in SDAI, CDAI or Boolean remission

From: Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition

  DAS28-CRP <1.9 (n = 178) DAS28-ESR <2.2 (n = 235)
No CDAI REM (n = 94) No SDAI REM (n = 84) No Boolean REM (n = 108) All
(n = 178)
No CDAI REM (n = 164) No SDAI REM (n = 154) No Boolean REM (n = 178) All
(n = 235)
SJC28 1.3 (1.9) 1.5 (1.9) 1.2 (1.8) 0.8 (1.5) 2.2 (2.8) 2.3 (2.9) 2.0(2.8) 1.6 (2.6)
0 (0.0–8.0) 0 (0.0–8.0) 0.0 (0.0–8.0) 0.0 (0.0–8.0) 1.0 (0.0–13.0) 1.0 (0.0–13.0) 1.0 (0.0–13.0) 0.0 (0.0–13.0)
TJC28 0.1 (0.3) 0.1 (0.2) 0.0 (0.2) 0.1 (0.3) 0.8 (1.3) 0.8 (1.2) 0.7 (1.1) 0.6 (1.0)
0 (0.0–1.0) 0 (0.0–1.0) 0.0 (0.0–1.0) 0.0 (0.0–1.0) 0.0 (0.0–5.0) 0.0 (0.0–5.0) 0.0 (0.0–5.0) 0.0 (0.0–5.0)
CRP (mg/l) 0.6 (0.8) 0.7 (0.9) 0.7 (0.9) 0.7 (1.0) 1.4 (4.1) 1.4 (4.2) 1.7 (4.8) 1.5 (4.2)
0.3 (0.2–5.1) 0.3 (0.2–5.1) 0.4 (0.2–5.2) 0.3 (0.2–7.1) 0.4 (0.2–39.7) 0.4 (0.2–39.7) 0.4 (0.2–39.7) 0.4 (0.2–39.7)
ESR (mm/h) 8.4 (10.6) 8.5 (9.8) 8.4 (10.3) 9.3 (12.4) 3.6 (3.1) 3.7 (3.1) 3.9 (3.3) 4.2 (3.5)
4.0 (0.0–57.0) 5.0 (0.0–45.0) 5.0 (0.0–57.0) 5.0 (.00–91) 3.0 (1.0–16.0) 3.0 (1.0–16.0) 3.0 (1.0–18.0) 3.0 (1.0–18.0)
PGA (mm VAS) 20.4 (14.8) 21.7 (15.2) 20.2 (13.9) 13.7 (13.7) 21.9 (17.8) 22.9 (18.1) 21.4 (17.4) 17.1 (17.0)
16.0 (0.0–61.0) 19.0 (0–61.0) 16.0 (0.0–61.0) 10.0 (0.0–61.0) 17.5 (0.0–89.0) 19.5 (0.0–89.0) 16.5 (0.0–89.0) 13.0 (0.0–89.0)
EGA (mm VAS) 14.6 (11.4) 15.4 (12.0) 12.2 (11.5) 9.8 (10.4) 14.3 (11.4) 14.7 (11.7) 13.0 (11.5) 11.4 (10.9)
12.0 (0.0–63.0) 13.0 (0–63.0) 9.0 (0.0–63.0) 7.0 (0.0–63.0) 11.5 (0.0–75.0) 12.0 (0.0–75.0) 10.0 (0.0–75.0) 9.0 (0.0–75.0)
HAQ 0.7 (0.6) 0.7 (0.6) 0.7 (0.6) 0.6 (0.5) 0.7 (0.6) 0.7 (0.6) 0.7 (0.6) 0.6 (0.6)
0.6 (0.0–2.0) 0.6 (0–2.0) 0.6 (0.0–2.0) 0.4 (0.0–2.0) 0.6 (0.0–2.3) 0.6 (0.0–2.3) 0.6 (0.0–2.3) 0.5 (0.0–2.3)
SDAI 5.0 (1.6) 5.3 (1.5) 4.6 (1.9) 3.3 (2.2) 6.7 (3.3) 7.0 (3.2) 6.3 (3.5) 5.2 (3.7)
4.7 (2.8–9.5) 4.9 (3.3–9.5) 4.4 (1.3–9.5) 3.1 (0.02–9.5) 5.8 (2.8–19.6) 6.1 (3.4–19.6) 5.6 (1.3–19.6) 4.6 (0.02–19.6)
CDAI 4.9 (1.6) 5.2 (1.5) 4.5 (1.9) 3.2 (2.3) 6.6 (3.3) 6.8 (3.2) 6.2 (3.5) 5.0 (3.7)
4.6 (2.8–9.5) 4.8 (2.9–9.5) 4.4 (1.2–9.5) 3.0 (0.0–9.5) 5.8 (2.8–19.6) 6.1 (3.2–19.6) 5.5 (0.0–19.6) 4.5 (0.0–19.6)
DAS28–CRP 1.7 (0.2) 1.7 (0.2) 1.6 (0.2) 1.5 (0.3) 2.1 (0.5) 2.1 (0.5) 2.0 (0.5) 1.9 (0.6)
1.7 (1.1–1.9) 1.7 (1.1–1.9) 1.7 (1.2–1.9) 1.6 (1.0–1.9) 2.0 (1.1–3.7) 2.0 (1.1–3.7) 2.0 (1.2–3.7) 1.8 (1.0–3.7)
DAS28–ESR 1.7 (0.7) 1.7 (0.7) 1.6 (0.7) 1.5 (0.8) 1.6 (0.5) 1.6 (0.5) 1.6 (0.5) 1.5 (0.5)
1.6 (0.4–3.4) 1.7 (0.5–3.4) 1.6 (0.2–3.4) 1.5 (0.0–3.4) 1.7 (0.4–2.2) 1.8 (0.5–2.2) 1.7 (0.2–2.2) 1.6 (0.0–2.2)
  1. Values are mean (SD) or median (range). SDAI simplified disease activity index CDAI clinical disease activity index, REM remission, SJC28 swollen joint count using 28 joints, TJC28 tender joint count using 28 joints, CRP C-reactive protein, ESR erythrocyte sedimentation rate, PGA patient global assessment, VAS visual analogue scale, EGA evaluator global assessment, HAQ health assessment questionnaire, DAS28-CRP disease activity score using 28 joint counts and C-reactive protein, DAS28-ESR disease activity score using 28 joint counts and erythrocyte sedimentation rate