Table 2 Levels of adipokines in patients with AS with and without radiographic spinal progression after 2 years
Adipokine | mSASSS progression ≥2 points (n = 29) | No mSASSS progression ≥2 points (n = 91) | P a | Syndesmophyte formation/progression (n = 25) | No new syndesmophyte formation/progression (n = 95) | P a |
|---|---|---|---|---|---|---|
Baseline | ||||||
Leptin, ng/mL | 10.5 ± 9.0 | 16.4 ± 13.7 | 0.003 | 10.2 ± 9.6 | 16.2 ± 13.4 | 0.003 |
APN, μg/mL | 10.1 ± 4.8 | 10.7 ± 4.4 | 0.366 | 9.5 ± 3.7 | 10.8 ± 4.6 | 0.210 |
HMW-APN, μg/mL | 4.95 ± 3.52 | 6.35 ± 4.15 | 0.045 | 4.53 ± 2.86 | 6.40 ± 4.22 | 0.026 |
Lipocalin-2, ng/mL | 308.4 ± 424.8 | 197.1 ± 188.8 | 0.668 | 257.9 ± 361.3 | 215.1 ± 238.9 | 0.851 |
Chemerin, ng/mL | 211.5 ± 54.2 | 222.6 ± 53.6 | 0.356 | 223.4 ± 57.8 | 219 ± 52.9 | 0.831 |
Omentin, ng/mL | 455.1 ± 168.3 | 425.8 ± 131.7 | 0.477 | 477.8 ± 164.7 | 421 ± 132.8 | 0.122 |
Resistin, ng/mL | 37.7 ± 27.9 | 30.4 ± 25.3 | 0.098 | 35.6 ± 25.4 | 31.3 ± 26.2 | 0.161 |
Visfatin, ng/mL | 44.7 ± 80.3 | 42.2 ± 58.9 | 0.484 | 39.98 ± 83.4 | 43.4 ± 58.7 | 0.151 |
Year 2 | ||||||
Leptin, ng/mL | 13.4 ± 12.8 | 17.5 ± 16.0 | 0.044 | 11.7 ± 9.8 | 17.7 ± 16.3 | 0.032 |
APN, μg/mL | 9.1 ± 3.8 | 11.0 ± 5.9 | 0.129 | 8.6 ± 3.6 | 11.1 ± 5.8 | 0.029 |
HMW-APN, μg/mL | 5.06 ± 3.31 | 5.99 ± 3.88 | 0.185 | 4.55 ± 2.8 | 6.08 ± 3.92 | 0.071 |
Lipocalin-2, ng/mL | 235 ± 229.3 | 273 ± 311.1 | 0.762 | 194.7 ± 160.3 | 281.8 ± 316.7 | 0.613 |
Chemerin, ng/mL | 216.2 ± 60.3 | 213 ± 56.7 | 0.990 | 218 ± 61.9 | 212.6 ± 56.4 | 0.893 |
Omentin, ng/mL | 444.7 ± 133.6 | 426.4 ± 134.6 | 0.359 | 452 ± 139.9 | 425.3 ± 132.6 | 0.268 |
Resistin, ng/mL | 47.4 ± 84.3 | 62.4 ± 204.8 | 0.332 | 49.8 ± 91 | 61.1 ± 200.4 | 0.500 |
Visfatin, ng/mL | 43.6 ± 70 | 42.6 ± 62.3 | 0.627 | 43.9 ± 75.2 | 42.6 ± 61.2 | 0.499 |