Table 6 Analysis of association of leptin and HMW-APN with radiographic spinal progression stratified by sex
OR unadjusted | 95% CI | OR adjusteda | 95% CI | |
|---|---|---|---|---|
Men (n = 82) | ||||
Outcome: no mSASSS progression ≥2 points after 2 years (logistic regression) | ||||
Leptin, ng/mL | 1.20 | 1.06 to 1.36 | 1.45 | 1.18 to 1.78 |
Leptin/BMI | 725.2 | 15.4 to 34099 | 4818.9 | 33.3 to 698123 |
HMW-APN μg/mL | 1.25 | 1.002 to 1.57 | 1.35 | 1.04 to 1.75 |
HMW-APN/BMI | 81.8 | 0.53 to 12683 | 186.4 | 0.63 to 54915 |
HMW-APN/APN | 40.5 | 2.01 to 813.9 | 173.6 | 4.03 to 7479 |
Outcome: no syndesmophyte formation/progression after 2 years (logistic regression) | ||||
Leptin, ng/mL | 1.06 | 0.97 to 1.16 | 1.34 | 1.11 to 1.62 |
Leptin/BMI | 54.5 | 1.99 to 1491 | 241.8 | 3.51 to 16651 |
HMW-APN, μg/mL | 1.20 | 0.97 to 1.48 | 1.21 | 0.95 to 1.53 |
HMW-APN/BMI | 55.3 | 0.37 to 8262 | 77.9 | 0.32 to 19249 |
HMW-APN/APN | 31.5 | 1.60 to 621.5 | 55.6 | 1.56 to 1973 |
Women (n = 38) | ||||
Outcome: no mSASSS progression ≥2 points after 2 years (logistic regression) | ||||
Leptin, ng/mL | 1.01 | 0.96 to 1.07 | 1.04 | 0.95 to 1.14 |
Leptin/BMI | 1.53 | 0.21 to 11.29 | 1.67 | 0.15 to 18.8 |
HMW-APN, μg/mL | 0.99 | 0.85 to 1.17 | 1.04 | 0.85 to 1.27 |
HMW-APN/BMI | 1.22 | 0.03 to 48.9 | 3.03 | 0.05 to 196.9 |
HMW-APN/APN | 0.69 | 0.02 to 30.4 | 0.47 | 0.003 to 68.6 |
Outcome: no syndesmophyte formation/progression after 2 years (logistic regression) | ||||
Leptin, ng/mL | 1.05 | 0.95 to 1.16 | 1.17 | 0.90 to 1.51 |
Leptin/BMI | 20.5 | 0.23 to 1872 | 18.7 | 0.06 to 5989 |
HMW-APN, μg/mL | 1.07 | 0.83 to 1.38 | 1.13 | 0.84 to 1.51 |
HMW-APN/BMI | 3.48 | 0.02 to 738.3 | 14.8 | 0.03 to 7869 |
HMW-APN/APN | 0.15 | 0.001 to 21.4 | 0.15 | 0.0004 to 59.5 |