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Table 2 Plasma glucose, blood pressure, total cholesterol, HDL-cholesterol, LDL-cholesterol, ApoA1 and ApoB in pre-symptomatic individuals and controls

From: Cardiovascular risk factors predate the onset of symptoms of rheumatoid arthritis: a nested case–control study

 

Pre-symptomatic individuals (n = 547)

Controls (n = 1641)

OR (95% CI)

Pre-symptomatic women (n = 372)

Control women (n = 1116)

OR (95% CI)

Pre-symptomatic men (n = 175)

Control men (n = 525)

OR (95% CI)

Plasma glucose, 0 hours (mmol/L)a

5.40 (5.05–5.84) (n = 513)

5.40 (5.00–5.80) (n = 1543)

1.11 (1.00–1.22)

5.40 (5.00–5.80) (n = 349)

5.38 (5.00–5.80) (n = 1052)

1.05 (0.92–1.21)

5.50 (5.10–6.00) (n = 164)

5.50 (5.10–5.90) (n = 491)

1.18 (1.01–1.37)

Plasma glucose, 2 hours (mmol/L)a

6.60 (5.70–7.30) (n = 470)

6.70 (5.90–7.60) (n = 1473)

0.94 (0.88–1.01)

6.67 (5.80–7.4) (n = 327)

6.80 (6.00–7.70) (n = 1005)

0.92 (0.85–1.00)

6.38 (5.40–7.10) (n = 143)

6.40 (5.40–7.40) (n = 468)

0.98 (0.87–1.10)

Systolic blood pressure (mmHg)a

128 (118–140) (n = 542)

129 (118–140) (n = 1637)

1.00 (0.99–1.01)

128 (115–140) (n = 368)

127 (118–140) (n = 1113)

1.00 (0.99–1.01)

128 (120–139) (n = 174)

130 (120–140) (n = 524)

1.00 (0.99–1.01)

Diastolic blood pressure (mmHg)a

80 (70–88) (n = 542)

80 (72–86) (n = 1635)

1.00 (0.99–1.01)

79 (70–87) (n = 368)

80 (70–85) (n = 1112)

1.00 (0.98–1.01)

80 (75–90) (n = 174)

80 (75–90) (n = 523)

1.00 (0.99–1.02)

Total cholesterol (mmol/L)a

5.74 (5.01–6.49) (n = 535)

5.70 (4.93–6.50) (n = 1619)

1.04 (0.96–1.14)

5.74 (5.01–6.57) (n = 361)

5.71 (4.94–6.57) (n = 1103)

1.04 (0.93–1.16)

5.76 (5.03–6.46) (n = 174)

5.70 (4.90–6.48) (n = 516)

1.06 (0.91–1.23)

Triglycerides (mmol/L)a

1.20 (0.89–1.60) (n = 453)

1.18 (0.84–1.70) (n = 1390)

0.95 (0.82–1.10)

1.16 (0.83–1.56) (n = 312)

1.14 (0.80–1.60) (n = 960)

0.95 (0.79–1.15)

1.29 (0.96–1.70) (n = 141)

1.36 (0.95–1.87) (n = 430)

0.94 (0.75–1.18)

HDL-cholesterol (mmol/L)a

1.26 (1.04–1.51) (n = 152)

1.32 (1.08–1.60) (n = 517)

0.81 (0.46–1.46)

1.30 (1.10–1.54) (n = 100)

1.40 (1.19–1.66) (n = 341)

0.65 (0.32–1.34)

1.19 (0.92–1.40) (n = 52)

1.14 (0.96–1.39) (n = 176)

1.60 (0.49–5.22)

LDL-cholesterol (mmol/L)a

4.13 (3.15–4.76) (n = 143)

4.07 (3.19–4.79) (n = 474)

1.12 (0.90–1.41)

4.08 (3.13–4.61) (n = 96)

4.02 (3.20–4.79) (n = 320)

1.06 (0.80–1.40)

4.28 (3.60–5.06) (n = 47)

4.14 (3.17–4.84) (n = 154)

1.25 (0.85–1.83)

ApoA1 (g/L)a

1.39 (1.23–1.57) (n = 453)

1.42 (1.28–1.59) (n = 1389)

0.50 (0.31–0.80)

1.46 (1.28–1.60) (n = 304)

1.47 (1.33–1.63) (n = 943)

0.49 (0.28–0.85)

1.31 (1.15–1.46) (n = 149)

1.32 (1.20–1.47) (n = 446)

0.53 (0.22–1.30)

ApoB (g/L)a

1.05 (0.86–1.24) (n = 453)

1.02 (0.86–1.21) (n = 1390)

1.50 (0.96–2.36)

1.02 (0.84–1.22) (n = 304)

1.00 (0.84–1.17) (n = 944)

1.66 (0.95–2.91)

1.11 (0.93–1.28) (n = 149)

1.09 (0.91–1.27) (n = 446)

1.24 (0.58–2.67)

Ratio ApoB/ApoA1

0.75 (0.60–0.93) (n = 453)

0.71 (0.58–0.88) (n = 1389)

2.05 (1.28–3.29)

0.70 (0.57–0.87) (n = 304)

0.67 (0.56–0.82) (n = 943)

2.25 (1.25–4.06)

0.86 (0.69–1.03) (n = 149)

0.82 (0.67–1.00) (n = 446)

1.74 (0.79–3.83)

  1. Data presented as median (Q1–Q3)
  2. Odds ratio (OR) and 95% confidence interval (CI) for future development of rheumatoid arthritis calculated with conditional logistic regression analyses for continuous variables in univariable analyses
  3. Apo apolipoprotein, HDL high-density lipoprotein, LDL low-density lipoprotein
  4. aOR per unit of increase