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Table 3 Odds ratio (95%) for association of risk factors for cardiovascular disease with future RA from univariable and multivariable conditional logistic regression models

From: Cardiovascular risk factors predate the onset of symptoms of rheumatoid arthritis: a nested case–control study

 

Elevated ApoB/ApoA1a

Smoking, everb

BMI ≥ 25.0c (kg/m2)

Diabetes

Hypertensiond

Cases

241 (52.9)

366 (67.8)

322 (59.9)

17 (3.1)

78 (14.3)

Controls

667 (47.0)

832 (51.3)

850 (52.7)

27 (1.6)

268 (16.3)

Univariable

1.25 (1.01–1.56)*

2.00 (1.63–2.47)***

1.33 (1.09–1.63)**

1.98 (1.06–3.68)*

0.89 (0.72–1.11)

Multivariable

1.19 (0.95–1.50)

1.86 (1.48–2.35)***

1.28 (1.01–1.62)*

1.75 (0.86–3.58)

0.87 (0.67–1.11)

Univariable, women

1.41 (1.09–1.84)*

1.92 (1.50–2.47)***

1.34 (1.06–1.71)*

1.11 (0.46–2.67)

1.01 (0.77–1.32)

Multivariable, women

1.36 (1.03–1.80)*

1.82 (1.37–2.41)***

1.16 (0.87–1.54)

1.11 (0.41–2.99)

0.99 (0.72–1.34)

Univariable, men

0.99 (0.68–1.43)

2.23 (1.53–3.27)***

1.31 (0.91–1.90)

4.73 (1.71–13.08)**

0.76 (0.52–1.09)

multivariable, men

0.94 (0.63–1.40)

1.92 (1.26–2.92)**

1.56 (1.01–2.39)*

3.62 (1.13–11.64)*

0.67 (0.43–1.03)

Univariable, age ≤ 50.19 years

1.51 (1.11–2.06)**

2.20 (1.62–2.98)***

1.45 (1.09–1.93)*

2.09 (0.56–7.84)

0.88 (0.62–1.26)

Multivariable, age ≤ 50.19 years

1.39 (1.00–1.93)*

2.11 (1.51–2.95)***

1.45 (1.04–2.02)*

1.34 (0.28–6.27)

0.79 (0.53–1.19)

Univariable, age > 50.19 years

1.18 (0.86–1.62)

1.93 (1.43–2.60)***

1.21 (0.91–1.62)

2.10 (1.02–4.36)*

0.91 (0.68–1.20)

Multivariable, age > 50.19 years

0.90 (0.65–1.26)

1.74 (1.24–2.45)**

1.09 (0.77–1.55)

2.07 (0.90–4.81)

0.90 (0.65–1.26)

  1. Data shown for all individuals overall, stratified for sex and age at 50.19 years
  2. Data presented as n (%) or odds ratio (95% confidence interval)
  3. Apo apolipoprotein, BMI body mass index, RA rheumatoid arthritis
  4. aMales > 0.8, females > 0.7 including lipid lowering therapy
  5. bSmoking ever compared with never smoking
  6. cBMI ≥ 25.0 compared with BMI < 25.0
  7. dSystolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg including treatment for hypertension compared with SBP < 140 mmHg and DBP < 90 mmHg and no ongoing hypertensive treatment
  8. * p ≤ 0.05,** p ≤ 0.01, *** p ≤ 0.001, dependent variable case/control