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Table 3 Factors associated with carotid plaques in SLE patients

From: High-sensitivity cardiac troponin T is a biomarker for atherosclerosis in systemic lupus erythematous patients: a cross-sectional controlled study

Ā 

No carotid plaque

(nā€‰=ā€‰40)

Carotid plaque

(nā€‰=ā€‰23)

p value

Age, years

36 (29ā€“59)

44 (30ā€“63)

<0.001

Female gender, n (%)

34 (85)

18 (78.3)

0.497

10-Year cardiovascular riska, %

1 (1ā€“9)

1.5 (1ā€“18)

0.002

Overweightb

9 (22.5)

15 (65.2)

<0.001

eGFRc, ml/min/1.73Ā m2

96 (56ā€“127)

76 (54ā€“122)

0.294

HbA1c, %

5.4 (4.4ā€“6.7)

5.5 (5ā€“6.4)

0.336

Detectable HS-cTnTd

17 (42.5)

20 (87)

<0.001

Proteinuria/creatininuria, mg/mmol

18.7 (5ā€“558)

22.7 (5ā€“234)

0.425

Duration of SLE disease, years

11 (1ā€“34)

14 (4ā€“37)

0.138

SELENA-SLEDAI score

2 (0ā€“13)

2 (0ā€“8)

0.593

Lupus nephritise, n (%)

19 (47.5)

14 (60.8)

0.306

AP antibodiesf, n (%)

13 (32.5)

9 (39.1)

0.595

APS, n (%)

4 (10)

4 (17.4)

0.396

Cumulative years of steroid treatment, years

6.5 (0ā€“16)

10 (0ā€“21)

0.075

Hormonal contraceptiong, n (%)

12/34 (35.3)

3/18 (16.7)

0.158

Hydroxychloroquine, n (%)

40 (100)

22 (95/6)

0.184

Immunosuppressive therapyh, n (%)

28 (70)

19 (82.6)

0.421

  1. Results are shown as median (range) or number (percentage)
  2. Analysis was performed on 63 subjects
  3. a10-year cardiovascular risk was calculated using the Framingham equation
  4. bOverweight was defined as a body mass index >25Ā kg/m2
  5. cEstimated glomerular filtration rate (eGRF) was calculated with the Modification of Diet in Renal Disease (MDRD) equation
  6. dDetectable HS-cTnT referred to a high-sensitivity cardiac troponin T (HS-cTnT) serum level >3Ā ng/L
  7. eLupus nephritis was class III or class IV
  8. fAntiphospholipid (AP) antibodies included lupus anticoagulant, anti-cardiolipin, or Ī²2-glycoprotein 1 antibodies
  9. gHormonal contraception was progestin-only pill in all cases
  10. hImmunosuppressive drugs included cyclophosphamide, azathioprine, mycophenolate mofetil, methotrexate, or rituximab
  11. APS antiphospholipid syndrome, HbA1c haemoglobin A1c, SELENA Safety of Estrogens in Lupus Erythematosus National Assessment, SLE systemic lupus erythematosus, SLEDAI Systemic Lupus Erythematosus Disease Activity Index