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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis

Fig. 5

Reduction of macrophages and CD4+ T cells accumulation in arthritic joints of Cxcl10 –/– and Cxcr3 –/– mice with CAIA. a, b Joint tissue sections from WT, Cxcl10 –/– (a), and Cxcr3 –/– (b) mice with CAIA used in Fig. 4 were stained with an IgG or an anti-F4/80 antibody. Representative images of F4/80 staining of joint tissue sections from each group (top panel) and quantification of F4/80-positive cells (bottom panel). IgG, negative control. Scale bar, 200 μm. Data represent mean ± SEM of results in five samples (n = 5). *P < 0.001 vs WT mice by unpaired Student’s t test. c, d Joint tissue sections from WT, Cxcl10 –/– (c), and Cxcr3 –/– (d) mice with CAIA used in Fig. 4 were stained with a control-FITC or an anti-CD4-FITC antibody. Representative images of CD4-FITC staining of joint tissue sections from each group (second and third topmost panels) and quantification of CD4-positive cells (bottom panel). Con-FITC, negative control. Scale bar, 20 μm. Data represent mean ± SEM of results in five samples (n = 5). *P < 0.001 vs WT mice by unpaired Student’s t test. WT wild-type, CXCL10 C-X-C motif chemokine 10, Cxcr3 CXC chemokine receptor 3, IgG immunoglobulin G, DAPI 4′,6-diamidino-2-phenylindole, FITC fluorescein isothiocyanate

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