Table 4 Number of micro-haemorrhages and micro-thromboses scores having best performance in terms of sensitivity/specificity ratio in predicting different degrees of disease activity according European Scleroderma Study Group index score cut-off values

Milan cohort

NEMO score ≥8 for ESSG score ≥3

NEMO score ≥9 for ESSG score ≥3.5

Sensitivity 86.0 (95% CI 74.2–93.7)

Specificity 87.7 (95% CI 77.2–94.5)

Sensitivity 86.7 (95% CI 73.2–94.9)

Specificity 81.8 (95% CI 71.4–89.7)

Naples cohort

NEMO score ≥11 for ESSG score ≥3

NEMO score ≥15 for ESSG score ≥3.5

Sensitivity 80.0 (95% CI 61.4–92.3)

Specificity 86.6 (95% CI 76.0–93.7)

Sensitivity 90.0 (95% CI 68.3–98.8)

Specificity 97.4 (95% CI 90.9–99.7)