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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Fig. 2

Histological analysis of CIA treated with CKD-L or Tubastatin A. Histological analyses were performed on knee joints (×40, ×100) and hind paws (×40) stained by H&E. Synovial inflammation, bone erosion, cartilage damage, and leukocyte infiltration were observed in the knee joints and hind paws of mice treated with vehicle (arrows) compared to Tubastatin A or CKD-L (a). The mean score of synovial inflammation (b), bone erosion (c), cartilage damage (d), and leukocyte infiltration (e) were calculated using a scale of 0–4 (normal = 0; mild = 1; moderate = 2; marked = 3; severe = 4), and these parameters significantly decreased after CKD-L or Tubastatin A treatment compared to vehicle treatment. Histological score was calculated by summation of these parameters (f). Histological score significantly decreased following treatment with CKD-L or Tubastatin A. *p < 0.001, **p < 0.01, vs vehicle

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