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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Fig. 8

Tumor necrosis factor (TNF) secretion in PMA-activated THP-1 cells (n = 3). THP-1 cells (1 × 105 cells/well) were cultured in a 24-well plate and activated with PMA (10 ng/ml) for 24 h to induce macrophage differentiation. PMA-activated THP-1 cells were treated with vehicle or HDAC inhibitors (0.1 to 10 μM) for 24 h and then treated with 100 ng/ml lipopolysaccharide (LPS) for 4 h. The secretion of TNF was measured by ELISA. *p < 0.001, vs LPS

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