Table 1 Patient characteristics

Female, n (%)

2046 (58.2)

1389 (70.8)

293 (35.1)

364 (50.5)

<0.001

Age in years, mean ± SD

55.1 ± 11.6

59.1 ± 11.2

48.4 ± 9.6

52.0 ± 10.0

<0.001

 Age 30 to <45 years, n (%)

774 (22.0)

245 (12.4)

338 (40.5)

191 (26.5)

-

 Age 45 to <60 years, n (%)

1485 (42.2)

729 (37.2)

385 (46.1)

371 (51.5)

-

 Age 60 to ≤80 years, n (%)

1258 (35.8)

987 (50.3)

112 (13.4)

159 (22.1)

-

Working/student, n (%)

1755 (52.4)

806 (43.0)

543 (68.4)

406 (59.9)

<0.001

Education in years, mean ± SD

12.9 ± 3.3

12.4 ± 3.3

13.8 ± 3.1

13.3 ± 3.0

<0.001

 Total cholesterol (mmol/l), mean ± SD

5.37 ± 1.1

5.38 ± 1.09

5.29 ± 1.05

5.41 ± 1.07

0.065

 Triglycerides (mmol/l), median (IQR)

1.30 (0.94, 1.86)

1.24 (0.93, 1.74)

1.34 (0.91, 1.92)

1.43 (1.00, 2.16)

<0.001

 LDL-c (mmol/l), mean ± SD

3.29 ± 0.97

3.27 ± 0.97

3.29 ± 0.96

3.37 ± 0.97

0.056

 HDL-c (mmol/l), mean ± SD

1.56 ± 0.51

1.64 ± 0.52

1.47 ± 0.48

1.45 ± 0.46

<0.001

 Body mass index (kg/m²), mean ± SD

26.5 ± 4.6

26.1 ± 4.5

26.4 ± 4.3

28.0 ± 4.9

<0.001

 Systolic BP (mmHg), mean ± SD

132.0 ± 17.1

132.1 ± 17.3

129.8 ± 16.7

133.9 ± 16.9

<0.001

 Diastolic BP (mmHg), mean ± SD

80.7 ± 9.5

80.0 ± 9.2

80.9 ± 10.1

82.4 ± 9.4

<0.001

 RF IgM+, n (%)

-

787 (66.5)

-

-

-

 ACPA+, n (%)

-

1066 (77.3)

-

-

-

 HLA-B27+, n (%)

-

-

445 (85.6)

-

-

Disease duration in years, median (IQR)

8.4 (3.8, 16.6)

8.3 (4.0, 15.4)

10.3 (3.8, 20.8)

7.6 (3.1, 15.3)

<0.001

ESR (mm/h), median (IQR)

9 (5, 17)

10 (5, 19)

7 (3, 15)

8 (4, 16)

0.095

CRP (mg/l), median (IQR)

3 (1, 5)

3 (1, 6)

3 (1, 5)

3 (1, 5)

<0.001

DAS28 (ESR), mean ± SD

-

2.59 ± 1.24

-

2.51 ± 1.28

-

 Remission (<2.6), n (%)

-

912 (55.2)

-

313 (55.9)

-

 Low disease activity (2.6 to <3.2), n (%)

-

273 (16.5)

-

90 (16.1)

-

 Moderate disease activity (3.2 to ≤5.1), n (%)

-

405 (24.5)

-

137 (24.5)

-

 High disease activity (>5.1), n (%)

-

63 (3.8)

-

20 (3.6)

-

ASDAS (CRP), median (IQR)

-

-

1.59 (1.04, 2.53)

1.54 (0.99, 2.31)

-

 Inactive (<1.3), n (%)

-

-

236 (37.8)

182 (40.4)

-

 Moderate (1.3 to <2.1), n (%)

-

-

165 (26.4)

129 (28.6)

-

 High (2.1 to ≤3.5), n (%)

-

-

184 (29.4)

112 (24.8)

-

 Very high (>3.5), n (%)

-

-

40 (6.4)

28 (6.2)

-

BASDAI, median (IQR)

-

-

1.29 (0.25, 4.13)

1.09 (0.26, 3.73)

-

 Glucocorticoids, n (%)

641 (18.2)

575 (29.3)

17 (2.0)

49 (6.8)

<0.001

 Methotrexate, n (%)

1451 (41.3)

1100 (56.1)

54 (6.5)

297 (41.2)

<0.001

 Other sDMARDs, n (%)

1925 (54.7)

1462 (74.6)

88 (10.5)

375 (52.0)

<0.001

 bDMARDs, n (%)

1750 (49.8)

848 (43.2)

518 (62.0)

384 (53.3)

<0.001