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Table 1 Cohort characteristics

From: IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

  Healthy control subjects (n = 32) Pregnant patients with RA (n = 252)       
Mean age at delivery in years (SD) 32.1 (4.4) 32.8 (3.7)       
Median disease duration in years at first visit (range)   4.9 (0.2-28.6)       
ACPA-positive patients, n (%)   153/252 (61)       
RF-positive patients, n (%)   161/239 (67)       
ACPA- and/or RF-positive patients, n (%)   181/252 (72)       
Erosive disease, n (%)   150/246 (61)       
Response during pregnancya, n (%)   56/120 (47)       
Flare during post-partum period, n (%)   69/223 (31)       
Per time point   Pre-conception First trimester Second trimester Third trimester 6 Weeks post-partum 12 Weeks post-partum 26 Weeks post-partum
DAS28, mean (SD)   3.6 (1.1) 3.6 (1.1) 3.6 (1.1) 3.3 (1.1) 3.3 (1.1) 3.6 (1.2) 3.4 (1.1)
Use of prednisone, n (%)   37/121 (31) 79/223 (35) 86/234 (37) 81/239 (34) 84/240 (35) 87/242 (36) 78/242 (32)
Use of sulphasalazine, n (%)   41/121 (34) 62/223 (28) 64/234 (27) 61/239 (26) 60/240 (25) 72/242 (30) 70/242 (29)
Use of hydroxychloroquine, n (%)   9/121 (7) 5/223 (2) 5/234 (2) 4/239 (2) 9/240 (4) 18/242 (7) 17/242 (7)
Use of methotrexate, n (%)   0/121 (0) 0/223 (0) 0/234 (0) 0/239 (0) 34/240 (14) 59/242 (24) 74/242 (31)
Use of leflunomide, n (%)   0/121 (0) 0/223 (0) 0/234 (0) 0/239 (0) 0/240 (0) 3/242 (1) 4/242 (2)
Use of TNF inhibitors, n (%)   5/121 (4) 0/223 (0) 0/234 (0) 0/239 (0) 13/240 (5) 23/242 (10) 29/242 (12)
  1. Abbreviations: ACPA Anti-citrullinated peptide antibodies, DAS28 Disease Activity Score in 28 joints, RA Rheumatoid arthritis, RF Rheumatoid factor, TNF Tumour necrosis factor
  2. aThe European League Against Rheumatism response criteria require a DAS28 > 3.2 at baseline