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Table 2 Interaction terms between alcohol consumption and 29 urate loci for the risk of gout in New Zealand study cohorts

From: Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout

SNP (% genotype data)a

Gene value

Effect allele

NZ European (n = 1039)

NZ Polynesian (n = 1753)

Interaction term (SE)

P value

Interaction term (SE)

P value

Alcohol intake as a continuous variable (per 50 g/week)

 rs10821905 (99.2)

A1CF

A

0.85 (0.07)

0.026

1.09 (0.08)

0.28

 rs2231142 (99.7)

ABCG2

T

0.99 (0.07)

0.89

0.92 (0.05)

0.19

 rs7976059 (98.9)

ACVR1B/ACVRL1

T

0.95 (0.07)

0.44

0.94 (0.07)

0.33

 rs653178 (99.3)

ATXN2

G

1.11 (0.07)

0.15

1.07 (0.09)

0.44

 rs11983997 (97.8)

MLXIPL/BAZ1B

G

0.60 (0.22)

0.022

–

–

 rs780094 (98.9)

GCKR

T

0.76 (0.08)

4.8 × 10−4

0.95 (0.06)

0.33

 rs7224610 (99.2)

HLF

C

0.97 (0.07)

0.68

1.04 (0.06)

0.59

 rs2941484 (98.9)

HNF4G

T

0.98 (0.07)

0.78

1.03 (0.06)

0.64

 rs6598541 (99.0)

IGF1R

A

0.92 (0.08)

0.31

1.08 (0.16)

0.61

 rs17050272 (99.0)

INHBB

A

0.99 (0.07)

0.96

0.98 (0.09)

0.78

 rs1106766 (98.5)

INHBC

C

0.90 (0.48)

0.83

1.04 (0.17)

0.84

 rs7188445 (98.8)

MAF

G

1.14 (0.14)

0.33

0.99 (0.08)

0.98

 rs7193778 (98.8)

NFAT5

C

0.92 (0.08)

0.30

1.12 (0.07)

0.12

 rs1394125 (98.6)

UBE2Q2

A

1.13 (0.07)

0.086

0.77 (0.12)

0.024

 rs1967017 (99.0)

PDZK1

T

0.98 (0.08)

0.85

1.01 (0.10)

0.90

 rs10480300 (98.0)

PRKAG2

T

0.95 (0.07)

0.45

1.17 (0.11)

0.16

 rs675209 (99.2)

RREB1

T

0.83 (0.07)

0.007

1.08 (0.15)

0.61

 rs6770152 (98.8)

SFMBT1

G

0.98 (0.07)

0.81

0.97 (0.07)

0.72

 rs1183201 (99.5)

SLC17A1

T

0.96 (0.10)

0.73

1.01 (0.10)

0.91

 rs2078267 (99.7)

SLC22A11

G

0.98 (0.08)

0.86

1.00 (0.22)

1.00

 rs3825018 (99.7)

SLC22A12

G

0.89 (0.06)

0.11

1.05 (0.11)

0.67

 rs12356193 (98.3)

SLC16A9

A

1.07 (0.29)

0.81

–

–

 rs11942223 (99.9)

SLC2A9

T

0.96 (0.21)

0.85

0.52 (2.74)

0.81

 rs17786744 (99.0)

STC1

G

1.08 (0.07)

0.29

1.11 (0.06)

0.055

 rs7953704 (99.2)

B3GNT4

G

0.99 (0.09)

0.90

1.04 (0.07)

0.52

 rs17632159 (98.6)

TMEM171

G

1.25 (0.14)

0.10

0.86 (0.11)

0.16

 rs11264341 (99.1)

TRIM46

C

1.01 (0.09)

0.95

1.03 (0.06)

0.63

 rs729761 (99.1)

VEGFA

G

1.11 (0.14)

0.46

0.99 (0.10)

0.98

 rs2544390 (79.4)

LRP2

T

0.92 (0.09)

0.34

0.72 (0.11)

0.004

Alcohol intake as a categorical variable (none vs. any intake)

 rs10821905 (99.2)

A1CF

A

0.29 (0.10)

0.28 (0.10)b

0.29 (0.11)c

1.4 × 10−4

6.3 × 10−4

1.0 × 10−3

1.27 (0.36)

0.40

 rs2231142 (99.7)

ABCG2

T

1.05 (0.38)

0.88

0.91 (0.23)

0.71

 rs7976059 (98.9)

ACVR1B/ACVRL1

T

0.75 (0.24)

0.38

0.72 (0.19)

0.22

 rs653178 (99.3)

ATXN2

G

1.90 (0.70)

0.082

0.91 (0.79)

0.79

 rs11983997 (97.8)

MLXIPL/BAZ1B

G

0.19 (0.19)

0.093

–

–

 rs780094 (98.9)

GCKR

T

0.28 (0.09)

0.22 (0.08)b

0.23 (0.09)c

1.5 × 10−4

5.8 × 10−58.5 × 10−5

0.62 (0.15)

0.54 (0.14)

0.53 (0.14)

0.05

0.02

0.02

 rs7224610 (99.2)

HLF

C

0.77 (0.25)

0.43

1.26 (0.34)

0.38

 rs2941484 (98.9)

HNF4G

T

1.79 (0.62)

0.092

1.36 (0.21)

0.21

 rs6598541 (99.0)

IGF1R

A

1.21 (0.40)

0.57

1.32 (0.84)

0.66

 rs17050272 (99.0)

INHBB

A

0.49 (0.16)

0.033

1.32 (0.46)

0.43

 rs1106766 (98.5)

INHBC

C

0.52 (0.36)

0.35

1.54 (0.86)

0.86

 rs7188445 (98.8)

MAF

G

1.92 (1.07)

0.24

0.98 (0.32)

0.95

 rs7193778 (98.8)

NFAT5

C

0.63 (0.23)

0.20

1.11 (0.31)

0.70

 rs1394125 (98.6)

UBE2Q2

A

2.38 (0.79)

0.009

0.63 (0.22)

0.18

 rs1967017 (99.0)

PDZK1

T

0.83 (0.30)

0.60

1.26 (0.48)

0.54

 rs10480300 (98.0)

PRKAG2

T

1.07 (0.34)

0.83

1.01 (0.42)

0.97

 rs675209 (99.2)

RREB1

T

0.68 (0.22)

0.23

1.33 (0.75)

0.61

 rs6770152 (98.8)

SFMBT1

G

1.26 (0.44)

0.51

1.07 (0.32)

0.82

 rs1183201 (99.5)

SLC17A1

T

0.53 (0.22)

0.12

1.80 (0.83)

0.20

 rs2078267 (99.7)

SLC22A11

G

1.20 (0.42)

0.60

0.60 (0.55)

0.58

 rs3825018 (99.7)

SLC22A12

G

1.27 (0.40)

0.45

1.00 (0.41)

0.99

 rs12356193 (98.3)

SLC16A9

A

1.03 (0.99)

0.97

–

–

 rs11942223 (99.9)

SLC2A9

T

0.83 (0.71)

0.82

1.12 (2.96)

0.97

 rs17786744 (99.0)

STC1

G

1.00 (0.34)

0.99

1.72 (0.43)

0.03

 rs7953704 (99.2)

B3GNT4

G

1.28 (0.52)

0.54

0.68 (0.24)

0.27

 rs17632159 (98.6)

TMEM171

G

1.71 (1.02)

0.37

0.38 (0.16)

0.022

 rs11264341 (99.1)

TRIM46

C

1.45 (0.59)

0.36

1.07 (0.27)

0.80

 rs729761 (99.1)

VEGFA

G

1.81 (0.97)

0.26

0.99 (0.41)

0.97

 rs2544390 (79.4)

LRP2

T

0.86 (0.34)

0.71

0.32 (0.12)

0.003

  1. NZ New Zealand, SNP Single-nucleotide polymorphism
  2. Regression analyses are adjusted for age, sex, and body mass index. The Polynesian analyses are additionally adjusted for STRUCTURE ancestry and ancestral class (Western vs. Eastern Polynesian vs. mixed Western/Eastern Polynesians). No data are presented for rs11983997 and rs12356193 in people of Polynesian ancestry, owing to the minor genotype group having very low frequency (<0.01)
  3. aFor each individual SNP, the number inside the parentheses represents the percentage of subjects with available genotype data
  4. bThe interaction term was additionally adjusted for triglycerides (mmol/L)
  5. cThe interaction term was additionally adjusted for estimated glomerular filtration rate (ml/minute/1.73 m2)
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Arthritis Research & Therapy

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