Table 3 Alcohol intake and gout association results in genotype-stratified groups in people of European ancestry for A1CF and GCKR
From: Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout
No alcohol intake (n = 297) | Any alcohol intake (n = 734) | ||||
|---|---|---|---|---|---|
Adjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | P Difference | |
A1CF | |||||
A− | 1 | 1 | 1.47 (0.99–2.16) | 0.054 | |
A+ | 2.21 (1.24–3.93) | 0.007 | 0.93 (0.61–1.43) | 0.76 | 0.011 |
Beer | |||||
A− | 1 | 1 | 1.66 (1.13–2.43) | 0.009 | |
A+ | 1.42 (0.96–2.10) | 0.077 | 0.79 (0.51–1.23) | 0.30 | 0.002 |
Nonbeer | |||||
A− | 1 | 1 | 0.97 (0.68–1.39) | 0.89 | |
A+ | 1.48 (0.92–2.39) | 0.10 | 0.63 (0.42–0.94) | 0.023 | 0.019 |
No alcohol intake (n = 296) | Any alcohol intake (n = 727) | ||||
GCKR | |||||
T− | 1 | 1 | 2.07 (1.24–3.47) | 0.0050 | |
T+ | 4.13 (2.35–7.26) | 8.65 × 10−7 | 2.39 (1.47–7.26) | 0.00043 | 0.51 |
Beer | |||||
T− | 1 | 1 | 1.57 (0.96–2.55) | 0.071 | |
T+ | 2.04 (1.39–3.00) | 0.0003 | 1.87 (1.22–2.88) | 0.004 | 0.54 |
Nonbeer | |||||
T− | 1 | 1 | 1.62 (1.01–2.59) | 0.046 | |
T+ | 3.56 (2.23–5.68) | 9.82 × 10−8 | 1.57 (1.03–2.40) | 0.037 | 0.77 |