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Table 3 Alcohol intake and gout association results in genotype-stratified groups in people of European ancestry for A1CF and GCKR

From: Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout

  No alcohol intake (n = 297) Any alcohol intake (n = 734)  
Adjusted OR (95% CI) P value Adjusted OR (95% CI) P value P Difference
A1CF
 A− 1 1 1.47 (0.99–2.16) 0.054  
 A+ 2.21 (1.24–3.93) 0.007 0.93 (0.61–1.43) 0.76 0.011
Beer
 A− 1 1 1.66 (1.13–2.43) 0.009  
 A+ 1.42 (0.96–2.10) 0.077 0.79 (0.51–1.23) 0.30 0.002
Nonbeer
 A− 1 1 0.97 (0.68–1.39) 0.89  
 A+ 1.48 (0.92–2.39) 0.10 0.63 (0.42–0.94) 0.023 0.019
  No alcohol intake (n = 296) Any alcohol intake (n = 727)  
GCKR
 T− 1 1 2.07 (1.24–3.47) 0.0050  
 T+ 4.13 (2.35–7.26) 8.65 × 10−7 2.39 (1.47–7.26) 0.00043 0.51
Beer
 T− 1 1 1.57 (0.96–2.55) 0.071  
 T+ 2.04 (1.39–3.00) 0.0003 1.87 (1.22–2.88) 0.004 0.54
Nonbeer
 T− 1 1 1.62 (1.01–2.59) 0.046  
 T+ 3.56 (2.23–5.68) 9.82 × 10−8 1.57 (1.03–2.40) 0.037 0.77
  1. Associations are adjusted for age, sex, and body mass index. P Difference is that between genotype groups in the alcohol-exposed subset